{"id":"W3193682442","doi":"10.1186/s12915-021-01077-2","title":"Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata","year":2021,"lang":"en","type":"article","venue":"BMC Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Functional Genomics Center Zurich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alberta Innovates; University of Bern; Swiss Re Foundation; National Science Foundation","keywords":"ESCRT; Biology; Endosome; Most recent common ancestor; Cell biology; Endocytic cycle; Genome; TSG101; Vacuole; Genetics; Gene; Microvesicles; Endocytosis; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024805,0.0003153374,0.0002347969,0.0008678379,0.00036734,0.0005123431,0.0001594775,0.0004527296,0.0007875399],"category_scores_gemma":[0.0001889628,0.0001540706,0.0002849716,0.0006736234,0.0002841736,0.000306781,0.0004316942,0.0004054588,0.0003014061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327381,"about_ca_system_score_gemma":0.0001622595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007545775,"about_ca_topic_score_gemma":0.001598195,"domain_scores_codex":[0.9998732,0.00000700869,0.000008575017,0.00006984507,0.0000157681,0.00002561073],"domain_scores_gemma":[0.9997677,0.00003135575,0.00009216098,0.00003139147,0.00003421573,0.00004317814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009815612,0.00001176412,0.01967878,0.0001249241,0.00002286332,0.0002929266,0.0002772591,0.00005713385,0.9753469,0.0001110233,0.0000644532,0.003913905],"study_design_scores_gemma":[0.000007685357,0.0002146981,0.9274933,0.00006130133,0.0001509749,0.002309131,0.0006869801,0.0005902568,0.05769238,0.0003252765,0.01044164,0.00002644046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932087,0.001722798,0.001550205,0.00006575283,0.00001082856,0.00001878078,0.002081409,0.00008552142,0.001256131],"genre_scores_gemma":[0.9895783,0.0007153224,0.004051215,0.00007956186,0.00001208863,0.0000333109,0.004503424,0.00003871483,0.0009881225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008678379,"threshold_uncertainty_score":0.002634525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892200776944325,"score_gpt":0.2608024396190595,"score_spread":0.2418804318496162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}