{"id":"W3193682442","doi":"10.1186/s12915-021-01077-2","title":"Unexpected organellar locations of ESCRT machinery in Giardia intestinalis and complex evolutionary dynamics spanning the transition to parasitism in the lineage Fornicata","year":2021,"lang":"en","type":"article","venue":"BMC Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Alberta","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Universität Zürich; Functional Genomics Center Zurich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alberta Innovates; University of Bern; Swiss Re Foundation; National Science Foundation","keywords":"ESCRT; Biology; Endosome; Most recent common ancestor; Cell biology; Endocytic cycle; Genome; TSG101; Vacuole; Genetics; Gene; Microvesicles; Endocytosis; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119495,0.00008150459,0.0001151642,0.00004090902,0.00004332205,0.000005002609,0.0001193502,0.000106528,0.00001081986],"category_scores_gemma":[0.00006897905,0.00006097432,0.00003819252,0.0002032715,0.0001037497,0.000002243111,0.00002973284,0.0001013662,7.963474e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001200818,"about_ca_system_score_gemma":0.00005870049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001999084,"about_ca_topic_score_gemma":0.005113302,"domain_scores_codex":[0.9992309,0.0001951978,0.0002139721,0.0002026584,0.00003855282,0.000118747],"domain_scores_gemma":[0.9996122,0.00005707722,0.00003807699,0.0002238522,0.00004999821,0.00001882831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009135254,0.0001046629,0.2190733,0.00003264824,0.00001747829,0.00001012596,0.0006761905,0.000895693,0.7770151,0.001628282,0.00004979472,0.0004053588],"study_design_scores_gemma":[0.0005735731,0.0001524071,0.9793311,0.00003504354,0.00002853267,0.0001205839,0.001363293,0.0106236,0.004559547,0.0003857152,0.00266057,0.000166061],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9153537,0.000928776,0.08239348,0.0009625391,0.0000344777,0.0001640519,0.00006046113,0.000003659721,0.00009884036],"genre_scores_gemma":[0.9900728,0.0001216432,0.001397084,0.0002424969,0.00004159088,0.00001715675,0.008086823,0.000006527837,0.00001384025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7724555,"threshold_uncertainty_score":0.2853343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892200776944325,"score_gpt":0.2608024396190595,"score_spread":0.2418804318496162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}