{"id":"W3193682641","doi":"10.1126/sciadv.abi6896","title":"Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Gene isoform; Phenotype; Spinal muscular atrophy; Transcriptional activity; Spinal and bulbar muscular atrophy; Gene; Biology; Genetics; Cancer research; Medicine; Bioinformatics; Gene expression; Cancer; Androgen receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545485,0.0004157531,0.0002968948,0.0003245175,0.0001489867,0.0002144407,0.000282182,0.0003751357,0.001351008],"category_scores_gemma":[0.0000686805,0.0001103655,0.0003821026,0.000155255,0.0002283085,0.0001702593,0.0001049434,0.0007373334,0.0003113909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874202,"about_ca_system_score_gemma":0.0002317766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007707844,"about_ca_topic_score_gemma":0.001737137,"domain_scores_codex":[0.9998939,0.00001361527,0.00001050175,0.00002970125,0.00002660707,0.0000257128],"domain_scores_gemma":[0.9999515,0.000006667884,0.00001787334,0.00000596399,0.000005069341,0.00001288769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140257,0.0001127733,0.00007510083,0.00002669195,0.00000692667,0.00006422913,0.00001515931,0.000107353,0.9968364,0.0001271372,0.00007865764,0.002409357],"study_design_scores_gemma":[0.000303076,0.005524214,0.004510547,0.00002042201,0.00007508321,0.000666587,0.00007953028,0.002306265,0.9752474,0.0001406299,0.01111027,0.00001593914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903381,0.001570851,0.004136694,0.0002228817,0.0001839121,0.0001029128,0.0005651969,0.0002639685,0.002615427],"genre_scores_gemma":[0.9840538,0.002305226,0.004263991,0.0001109351,0.00005336081,0.00009338813,0.0008155987,0.00005714492,0.008246538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351008,"threshold_uncertainty_score":0.004519522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01810571558729494,"score_gpt":0.3064939622651671,"score_spread":0.2883882466778721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}