{"id":"W3193682641","doi":"10.1126/sciadv.abi6896","title":"Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Medical Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Gene isoform; Phenotype; Spinal muscular atrophy; Transcriptional activity; Spinal and bulbar muscular atrophy; Gene; Biology; Genetics; Cancer research; Medicine; Bioinformatics; Gene expression; Cancer; Androgen receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319796,0.0001320288,0.0001809623,0.00007151086,0.0003424341,0.00005470595,0.0001186877,0.00002687568,0.00004489048],"category_scores_gemma":[0.00004806913,0.00009663406,0.0000495295,0.0005492658,0.0007884763,0.0003752866,0.00003227783,0.0001506588,0.000003086902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002722738,"about_ca_system_score_gemma":0.0003219793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002069226,"about_ca_topic_score_gemma":0.00001203941,"domain_scores_codex":[0.9981646,0.00003074061,0.000105627,0.0005136202,0.0008162321,0.0003691569],"domain_scores_gemma":[0.9993495,0.00001436592,0.00003418367,0.0002402678,0.0001927818,0.0001689371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002270726,0.00009806817,0.002744185,0.00003368518,0.00001594076,0.00002704038,0.00009189924,0.00005062694,0.8538896,0.00005554408,0.000004167464,0.1427622],"study_design_scores_gemma":[0.002461745,0.001741913,0.1386523,0.00009844524,0.00003203718,0.00015261,0.0005390216,0.0006182131,0.8427774,0.0006014157,0.01201489,0.0003100159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770619,0.01905869,0.00247497,0.0007435806,0.00004883539,0.0002182137,0.000005193523,0.00002267636,0.0003659004],"genre_scores_gemma":[0.9908257,0.002372114,0.006353046,0.0002192134,0.00005179417,0.00001610494,0.000004856413,0.0000125483,0.0001446994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1424522,"threshold_uncertainty_score":0.3940623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01810571558729494,"score_gpt":0.3064939622651671,"score_spread":0.2883882466778721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}