{"id":"W3193683222","doi":"10.1016/j.biopsych.2021.07.025","title":"Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Maternal Mental Health During Pregnancy and Postpartum","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of British Columbia; McGill University; Douglas Mental Health University Institute","funders":"National Medical Research Council; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Jacobs Foundation; R. Howard Webster Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Medical Research Council; Koninklijke Nederlandse Akademie van Wetenschappen; Canadian Institute for Advanced Research; Canadian Institutes of Health Research; Brain and Behavior Research Foundation; JPB Foundation; Hope for Depression Research Foundation; Canada First Research Excellence Fund; Agency for Science, Technology and Research","keywords":"Epigenetics; Anxiety; Cohort; Prenatal stress; Medicine; Pregnancy; Biology; Genetics; Psychiatry; Internal medicine; Offspring","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001437026,0.00009014035,0.000206074,0.00001211576,0.00006171784,0.000007397834,0.00005737864,0.00006981335,0.0001360465],"category_scores_gemma":[0.0000193809,0.00004720734,0.00007365708,0.00005192768,0.0001724607,0.0000140975,0.00006535807,0.0001413234,0.000008687258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001392696,"about_ca_system_score_gemma":0.00004815004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004804225,"about_ca_topic_score_gemma":0.000005835239,"domain_scores_codex":[0.9992543,0.00008184913,0.000224838,0.0001777175,0.0000954497,0.0001658524],"domain_scores_gemma":[0.9996402,0.00004208257,0.00006344842,0.0001520702,0.00001822877,0.00008402154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005005228,0.0000873743,0.9849834,0.0008267637,0.00003024996,0.00001335611,0.00004425559,2.510808e-7,0.0002396412,0.01161487,0.000017359,0.001641912],"study_design_scores_gemma":[0.002542781,0.0002177295,0.982192,0.001465211,0.000040693,0.0007089404,0.00006109173,0.00003021309,0.008484934,0.002179826,0.001981374,0.00009515211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986685,0.008860072,0.00003183838,0.002449048,0.0006968061,0.0001676455,0.00001627156,0.00002004727,0.001073253],"genre_scores_gemma":[0.9964406,0.00134887,0.001003891,0.0008136707,0.0001962693,0.00000854464,0.000008370392,0.000004867078,0.0001749514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009755548,"threshold_uncertainty_score":0.1925059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940035409770037,"score_gpt":0.2892035351905675,"score_spread":0.2698031810928672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}