{"id":"W3193702715","doi":"10.1042/bio_2021_142","title":"The next generation of RNA vaccines: self-amplifying RNA","year":2021,"lang":"en","type":"article","venue":"The Biochemist","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"RNA; RNA-dependent RNA polymerase; Messenger RNA; Biology; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008777914,0.0003516511,0.0004266265,0.0003956497,0.0002751419,0.001144232,0.0003551307,0.001013615,0.002390357],"category_scores_gemma":[0.0007430359,0.0002426818,0.0003895474,0.0001806457,0.00096173,0.001833946,0.0005116236,0.001976285,0.001493415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006729705,"about_ca_system_score_gemma":0.0005671319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002653196,"about_ca_topic_score_gemma":0.0003718735,"domain_scores_codex":[0.9996387,0.00009718524,0.00001566619,0.000059988,0.0001394837,0.00004911043],"domain_scores_gemma":[0.9996918,0.000132809,0.00004760925,0.00002124212,0.00006156972,0.00004500389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000264556,0.0001982744,0.001111919,0.001783349,0.0000543981,0.000522672,0.0005172529,0.001469972,0.471669,0.1227046,0.02437033,0.3753337],"study_design_scores_gemma":[0.00003747127,0.0007673647,0.0005575942,0.0002772166,0.00005029603,0.001371168,0.000166249,0.002285553,0.1827696,0.02314746,0.7885167,0.00005327905],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04398951,0.6636848,0.1874441,0.05192211,0.00731359,0.0001850304,0.0003197699,0.001364363,0.04377672],"genre_scores_gemma":[0.3106912,0.4628626,0.1482451,0.02105137,0.003976802,0.0003180657,0.0005470123,0.0004043322,0.0519035],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002390357,"threshold_uncertainty_score":0.007996559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263763263461322,"score_gpt":0.2660326350142529,"score_spread":0.2233950023796397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}