{"id":"W3193702715","doi":"10.1042/bio_2021_142","title":"The next generation of RNA vaccines: self-amplifying RNA","year":2021,"lang":"en","type":"article","venue":"The Biochemist","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"RNA; RNA-dependent RNA polymerase; Messenger RNA; Biology; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701353,0.0001105224,0.00008735041,0.00000664541,0.0001928838,0.00005545266,0.0002906577,0.00008077094,0.00002138862],"category_scores_gemma":[0.00008465052,0.00006922556,0.00009617489,0.00008128289,0.00004882336,0.000002965443,0.0001270173,0.00006587631,0.00001075026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009608195,"about_ca_system_score_gemma":0.00009892763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000129014,"about_ca_topic_score_gemma":0.00002129733,"domain_scores_codex":[0.9992895,0.00004207161,0.0001951459,0.0002089666,0.0001050139,0.0001593319],"domain_scores_gemma":[0.9991177,0.00002135084,0.00009109218,0.0005489936,0.0001893505,0.00003152062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001795409,0.00002261575,0.00006248084,0.00001139179,0.00006266405,9.20809e-7,0.00005690032,0.000008716433,0.9897354,0.0000401086,0.007829051,0.002151812],"study_design_scores_gemma":[0.0001422011,0.00003753994,0.00008562262,0.000009855635,0.00002249776,0.00001202146,0.0002611914,0.0001255368,0.9857744,0.0000378408,0.01339973,0.00009156631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908084,0.005775887,0.0001839706,0.000569453,0.0001866188,0.00006493617,0.000006740039,0.00000875165,0.002395193],"genre_scores_gemma":[0.9955815,0.001875629,0.0001396355,0.0002440447,0.0005537205,0.00001235867,0.00007487917,0.00001176063,0.00150645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005570681,"threshold_uncertainty_score":0.2822936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263763263461322,"score_gpt":0.2660326350142529,"score_spread":0.2233950023796397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}