{"id":"W3193758380","doi":"10.1016/j.jcmgh.2021.08.004","title":"SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis","year":2021,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Côte d’Azur; Société Francophone du Diabète; Association Française pour l'Etude du Foie; University of Toronto; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Syk; Steatohepatitis; Cancer research; Biology; Fatty liver; Inflammation; Immunology; Medicine; Tyrosine kinase; Signal transduction; Internal medicine; Cell biology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713734,0.0003365863,0.000206468,0.0002765257,0.0001569096,0.000216458,0.00009069803,0.0002502805,0.001570838],"category_scores_gemma":[0.0001074358,0.0001102235,0.000195968,0.0001449366,0.0003385798,0.0001419263,0.0002262125,0.0004752412,0.0002235532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001956588,"about_ca_system_score_gemma":0.0001600259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001455032,"about_ca_topic_score_gemma":0.0002319262,"domain_scores_codex":[0.9999126,0.0000187807,0.000007204857,0.00001792578,0.00002224282,0.00002125765],"domain_scores_gemma":[0.9998935,0.00001036572,0.00004414343,0.000006606355,0.000008868433,0.00003652154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001203058,0.00006126009,0.01370352,0.00008076181,0.00002124614,0.0007019402,0.00002070404,0.00007545827,0.9807623,0.0002215014,0.000102281,0.003045905],"study_design_scores_gemma":[0.0001570565,0.001371975,0.3738579,0.00004137483,0.0001618404,0.01215996,0.000222913,0.002498738,0.6051911,0.0007255296,0.003595299,0.00001628852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965978,0.001408632,0.001131321,0.0001046136,0.00001115811,0.00001339592,0.0001069145,0.0000258506,0.0006002085],"genre_scores_gemma":[0.9984214,0.0004305318,0.0005340587,0.00002649557,0.000009921078,0.00001361578,0.0001232139,0.000004369538,0.000436483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570838,"threshold_uncertainty_score":0.005255044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008506556269348004,"score_gpt":0.2199023665656544,"score_spread":0.2113958102963064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}