{"id":"W3193774255","doi":"10.1186/s13148-021-01151-0","title":"Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain","year":2021,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep Edouard Montpetit; McGill University; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Hospital for Sick Children; Université de Montréal; Sick Kids Foundation","keywords":"DNA methylation; Reprogramming; Epigenetics; Forebrain; Methylation; Biology; Fetus; Fetal alcohol syndrome; Genomic imprinting; Genetics; DNA; Neuroscience; Pregnancy; Cell; Gene; Gene expression; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002335004,0.0002017418,0.0004161133,0.00007528977,0.0001130356,0.00006327236,0.0001831455,0.0002794706,0.00001182255],"category_scores_gemma":[0.002595737,0.0001595846,0.0001313101,0.000626564,0.0001038465,0.00009730468,0.00007417612,0.0006180818,0.00001378346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007496242,"about_ca_system_score_gemma":0.0002302301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005007537,"about_ca_topic_score_gemma":0.000135659,"domain_scores_codex":[0.9970119,0.0006871739,0.001017059,0.000488742,0.0004080006,0.0003871327],"domain_scores_gemma":[0.9968467,0.002233833,0.0002493727,0.0004108259,0.0001562401,0.0001030765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001403426,0.0003139562,0.2891129,0.0002072823,0.00008693122,0.0002935332,0.004585324,0.0001819858,0.01651419,0.0005523114,0.00008750457,0.6879237],"study_design_scores_gemma":[0.002194595,0.0004664286,0.9484662,0.0004846044,0.00006770517,0.00008315387,0.001357203,0.0004103743,0.03974106,0.0009832302,0.00543947,0.0003059131],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987029,0.001529311,0.009070031,0.0008533453,0.0004737945,0.0007489,0.000003659805,0.00006451764,0.0002274847],"genre_scores_gemma":[0.9720383,0.0002722747,0.02642898,0.0005811053,0.0004488649,0.00006204871,0.00009328569,0.00003148125,0.00004367107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6876178,"threshold_uncertainty_score":0.650767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09360501136079807,"score_gpt":0.3807699293412448,"score_spread":0.2871649179804467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}