{"id":"W3193774255","doi":"10.1186/s13148-021-01151-0","title":"Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain","year":2021,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Prenatal Substance Exposure Effects","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep Edouard Montpetit; McGill University; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Hospital for Sick Children; Université de Montréal; Sick Kids Foundation","keywords":"DNA methylation; Reprogramming; Epigenetics; Forebrain; Methylation; Biology; Fetus; Fetal alcohol syndrome; Genomic imprinting; Genetics; DNA; Neuroscience; Pregnancy; Cell; Gene; Gene expression; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009859071,0.0002347178,0.0001789246,0.0004504354,0.0001133551,0.0001916903,0.0001825092,0.0002273566,0.002404928],"category_scores_gemma":[0.0001729958,0.0001577368,0.0001774622,0.0001119578,0.0002732674,0.0001416685,0.0002748957,0.0004826316,0.0002529667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002431079,"about_ca_system_score_gemma":0.0001922755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000814534,"about_ca_topic_score_gemma":0.00182367,"domain_scores_codex":[0.9998746,0.00001348933,0.00001108699,0.00004193062,0.00003057097,0.00002832783],"domain_scores_gemma":[0.9997858,0.00003583186,0.00008407133,0.00003139443,0.00001931363,0.00004358515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001677438,0.00001945204,0.001891225,0.00001682058,0.000006992257,0.0001261318,0.00003317735,0.00001701203,0.9956183,0.00005959844,0.00002053814,0.002023053],"study_design_scores_gemma":[0.00001075157,0.0005711401,0.08249419,0.00001477144,0.00003415687,0.001040238,0.0001395561,0.0002699003,0.914162,0.0001099877,0.001146228,0.000007001209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966253,0.0008795274,0.001381764,0.00005289423,0.00001837894,0.00001265954,0.0003175201,0.0000603066,0.0006516021],"genre_scores_gemma":[0.9953347,0.0007807133,0.001007672,0.00004392465,0.000005825754,0.00002595564,0.0003972183,0.00001948163,0.002384624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002404928,"threshold_uncertainty_score":0.008045316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09360501136079807,"score_gpt":0.3807699293412448,"score_spread":0.2871649179804467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}