{"id":"W3193811212","doi":"10.1021/acsomega.1c03315","title":"On the Viability of Tadalafil-Based <sup>18</sup>F-Radiotracers for <i>In Vivo</i> Phosphodiesterase 5 (PDE5) PET Imaging","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Tadalafil; In vivo; Cyclic guanosine monophosphate; cGMP-specific phosphodiesterase type 5; Positron emission tomography; Phosphodiesterase; Chemistry; Pharmacology; Nitric oxide; Medicine; Biochemistry; Nuclear medicine; Enzyme; Biology; Internal medicine; Erectile dysfunction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003425031,0.0001693531,0.0001834584,0.00003702745,0.00009503994,0.00002720637,0.0001355475,0.00006722547,0.00005302527],"category_scores_gemma":[0.0004196218,0.0001346186,0.0001463872,0.0001510771,0.0001187776,0.000007808599,0.00004097287,0.00009250353,0.000002144441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004147844,"about_ca_system_score_gemma":0.0001461473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002188208,"about_ca_topic_score_gemma":0.00003805686,"domain_scores_codex":[0.9988587,0.0001035363,0.0002820375,0.000376107,0.0001445205,0.000235043],"domain_scores_gemma":[0.9989741,0.0001915424,0.0001202606,0.0005118003,0.0001477155,0.00005461966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001098348,0.0005499207,0.01409938,0.0001752716,0.00009922575,0.00002380282,0.0002417569,0.01619921,0.9354946,0.0009866835,0.02865171,0.002380082],"study_design_scores_gemma":[0.001454677,0.0001344867,0.001353318,0.00004311509,0.00002300733,0.00001165757,0.0002132883,0.004356495,0.9509335,0.0002948258,0.04097021,0.0002114256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994656,0.0003302988,0.0019313,0.001562106,0.0001808389,0.0003731321,0.00009760279,0.00001225125,0.0008564253],"genre_scores_gemma":[0.9966598,0.00002462598,0.0003918694,0.001906906,0.00006921911,0.00007726183,0.0001340489,0.00002156101,0.0007147041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01543888,"threshold_uncertainty_score":0.5489586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009844770326678581,"score_gpt":0.2403999962159222,"score_spread":0.2305552258892436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}