{"id":"W3193811212","doi":"10.1021/acsomega.1c03315","title":"On the Viability of Tadalafil-Based <sup>18</sup>F-Radiotracers for <i>In Vivo</i> Phosphodiesterase 5 (PDE5) PET Imaging","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Tadalafil; In vivo; Cyclic guanosine monophosphate; cGMP-specific phosphodiesterase type 5; Positron emission tomography; Phosphodiesterase; Chemistry; Pharmacology; Nitric oxide; Medicine; Biochemistry; Nuclear medicine; Enzyme; Biology; Internal medicine; Erectile dysfunction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005647444,0.000451265,0.0002854934,0.0001667189,0.0002692093,0.0009446514,0.0005067869,0.0005140685,0.002924424],"category_scores_gemma":[0.0007043187,0.00026302,0.0002130981,0.0001483451,0.0003502269,0.000664095,0.0002548669,0.0005257915,0.001177135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691109,"about_ca_system_score_gemma":0.0003661427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001239561,"about_ca_topic_score_gemma":0.001666709,"domain_scores_codex":[0.9997492,0.00009161622,0.000009132735,0.0000591309,0.0000430617,0.00004776407],"domain_scores_gemma":[0.999693,0.0001566219,0.00004392694,0.00003390066,0.00004807735,0.00002446194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001559922,0.00006214414,0.0009649938,0.000382532,0.00005828194,0.0002787892,0.0001342149,0.0006156173,0.9385195,0.003767004,0.002626908,0.05102994],"study_design_scores_gemma":[0.00004525744,0.001130356,0.005876842,0.00008789806,0.0002297628,0.001279503,0.0001204757,0.005154086,0.945029,0.0006014449,0.04041406,0.00003127256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8410109,0.07612884,0.03617553,0.003242526,0.0006043831,0.0001221996,0.00151383,0.0004906496,0.04071125],"genre_scores_gemma":[0.9540281,0.02141786,0.01189171,0.001148198,0.0001822451,0.00008485802,0.001356753,0.0001971541,0.009693151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002924424,"threshold_uncertainty_score":0.009783149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009844770326678581,"score_gpt":0.2403999962159222,"score_spread":0.2305552258892436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}