{"id":"W3193827301","doi":"10.3390/cells10082081","title":"Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research","funders":"China Scholarship Council; Technische Universität München; Wilhelm Sander-Stiftung","keywords":"CD80; CD86; Cell biology; Biology; Exosome; Dendritic cell; Extracellular vesicle; Cancer research; Microvesicles; Immune system; T cell; Immunology; Cytotoxic T cell; CD40; microRNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199545,0.0001690536,0.0001206354,0.00002805446,0.0001200057,0.00007812605,0.0000919772,0.0001483993,0.00006960973],"category_scores_gemma":[0.00003399291,0.0001908101,0.00008404072,0.00007728041,0.00007118714,0.00001201438,0.0001117228,0.00009971831,0.00004089097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001455614,"about_ca_system_score_gemma":0.00007159821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002486037,"about_ca_topic_score_gemma":0.000005260389,"domain_scores_codex":[0.9988772,0.0001085516,0.0002070148,0.000435564,0.0001241155,0.000247558],"domain_scores_gemma":[0.9993191,0.00001863271,0.00006692956,0.0003758432,0.00008256871,0.0001369735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005083403,0.0000916576,0.0003193645,0.00007394957,0.00002009561,0.00005642986,0.00004386916,0.00003392933,0.996175,0.00004296698,0.0008626834,0.002229231],"study_design_scores_gemma":[0.0005042662,0.0000757208,0.00222174,0.00001600833,0.0000551696,0.00002871667,0.0002246865,0.0002711128,0.9872198,0.0002128115,0.008946791,0.000223207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743397,0.01810912,0.006440856,0.00006338229,0.0002835663,0.0001301697,0.00001045381,0.00002885721,0.0005938882],"genre_scores_gemma":[0.9952852,0.0003103484,0.001957222,0.0001761023,0.0002423015,0.00001024594,0.0001862459,0.0000360296,0.001796322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02094547,"threshold_uncertainty_score":0.7781008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006912159950622229,"score_gpt":0.2103849314847614,"score_spread":0.2034727715341392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}