{"id":"W3193827301","doi":"10.3390/cells10082081","title":"Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research","funders":"China Scholarship Council; Technische Universität München; Wilhelm Sander-Stiftung","keywords":"CD80; CD86; Cell biology; Biology; Exosome; Dendritic cell; Extracellular vesicle; Cancer research; Microvesicles; Immune system; T cell; Immunology; Cytotoxic T cell; CD40; microRNA; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397484,0.0002541118,0.0001943325,0.0001043244,0.00006492488,0.0002325338,0.00007501621,0.0002259336,0.0006720081],"category_scores_gemma":[0.000124269,0.00007714331,0.0001593273,0.0000665953,0.0001422283,0.0002406642,0.0002111837,0.0003672422,0.0001772102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234824,"about_ca_system_score_gemma":0.0001195338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476849,"about_ca_topic_score_gemma":0.0001888965,"domain_scores_codex":[0.9998536,0.00003075616,0.00002028948,0.00002550671,0.00003185831,0.00003799231],"domain_scores_gemma":[0.9999461,0.00001128234,0.00001715169,0.0000068298,0.000005495555,0.00001312472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008918948,0.00001570193,0.0001468695,0.00003606035,0.000003876432,0.00003695037,0.000009239389,0.00004773263,0.9986054,0.0001130677,0.00002205147,0.0008737765],"study_design_scores_gemma":[0.00001463749,0.0003007363,0.003227392,0.000007648413,0.0000134213,0.000356983,0.0000403681,0.0005034827,0.9922909,0.0001011614,0.003140398,0.000002865817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953378,0.001821347,0.001760444,0.00005063279,0.00002462201,0.00001808425,0.0002040472,0.00002955554,0.0007533565],"genre_scores_gemma":[0.9974776,0.0007516588,0.0004829334,0.00002199663,0.000004066939,0.00001305392,0.0002353239,0.000006867788,0.00100661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006720081,"threshold_uncertainty_score":0.002248108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006912159950622229,"score_gpt":0.2103849314847614,"score_spread":0.2034727715341392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}