{"id":"W3193829125","doi":"10.1016/j.bbamcr.2021.119123","title":"Isoginkgetin leads to decreased protein synthesis and activates an ATF4-dependent transcriptional response","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Spliceosome; ATF4; RNA splicing; Biology; Integrated stress response; Gene expression; Molecular biology; Gene; Transcription (linguistics); Cell biology; Intron; Unfolded protein response; Translation (biology); Genetics; Messenger RNA; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001966006,0.0004894853,0.0005335304,0.0004420074,0.0002018906,0.0004438865,0.0003577556,0.000453654,0.00268017],"category_scores_gemma":[0.0002022241,0.0002667845,0.0004692647,0.0002676481,0.0004636251,0.0001983224,0.0002116705,0.001408241,0.0004386843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008504401,"about_ca_system_score_gemma":0.0003617057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001447767,"about_ca_topic_score_gemma":0.001245723,"domain_scores_codex":[0.9996847,0.000070982,0.00002762138,0.00005369277,0.00007508499,0.00008796838],"domain_scores_gemma":[0.9997202,0.00006844494,0.00004902916,0.0000557242,0.00002821524,0.00007848351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005694702,0.00004711343,0.00006335658,0.00001906836,0.00000597504,0.00006355035,0.000007127208,0.00002243425,0.9987859,0.00005472565,0.00002785004,0.0003334793],"study_design_scores_gemma":[0.00003769532,0.0001443131,0.00179652,0.000003097377,0.00001259524,0.0001354997,0.00002773209,0.0002572951,0.996752,0.00005913229,0.0007700902,0.000003993998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927408,0.001295867,0.002747322,0.0003405618,0.0001134191,0.00004778577,0.0006848284,0.0002511587,0.001778365],"genre_scores_gemma":[0.992894,0.0004214018,0.001718277,0.0001412245,0.00002139096,0.00005226049,0.001015913,0.00006349697,0.003672117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00268017,"threshold_uncertainty_score":0.008966088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02768237358368057,"score_gpt":0.3200878820926908,"score_spread":0.2924055085090102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}