{"id":"W3193843934","doi":"10.1016/j.jacbts.2021.07.007","title":"Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction","year":2021,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"Bristol-Myers Squibb","keywords":"Ventricular remodeling; Inflammation; Agonist; Receptor; Myocardial infarction; Macrophage; Phagocytosis; Chemotaxis; Apoptosis; Internal medicine; Downregulation and upregulation; Pharmacology; Monocyte; Medicine; Cardiac function curve; M2 Macrophage; Endocrinology; Cell biology; Immunology; Chemistry; Biology; In vitro; Gene; Heart failure; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171172,0.000336671,0.00027523,0.0001542392,0.0001142479,0.0002161461,0.0001194825,0.0002472277,0.001253834],"category_scores_gemma":[0.00006576937,0.00009512938,0.0001189183,0.00007610509,0.0001443262,0.000141007,0.0001193431,0.0005161023,0.0002604969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334381,"about_ca_system_score_gemma":0.0001373673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001903545,"about_ca_topic_score_gemma":0.0007793241,"domain_scores_codex":[0.999941,0.00001162503,0.000003742028,0.000008369336,0.00001352397,0.00002186876],"domain_scores_gemma":[0.9999748,0.00000182332,0.00000806582,0.000001803361,0.000002833746,0.00001060107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001104709,0.0001620964,0.0002002601,0.00004475448,0.00001007883,0.00007230322,0.00001089908,0.00005767386,0.992916,0.0001281209,0.0001281157,0.005165041],"study_design_scores_gemma":[0.000590033,0.0100468,0.0175453,0.00003239135,0.00008063464,0.0009260033,0.0001184142,0.001151854,0.9632462,0.0002442838,0.006004116,0.0000139202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953895,0.001893017,0.0007964348,0.0001925179,0.00003015308,0.00002488219,0.0001323037,0.00005599124,0.001485235],"genre_scores_gemma":[0.9948003,0.00154671,0.0007657327,0.0001191319,0.0000212244,0.00003138624,0.0001767385,0.000007914218,0.002530831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253834,"threshold_uncertainty_score":0.004194498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004469414097766478,"score_gpt":0.2224866853574121,"score_spread":0.2180172712596457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}