{"id":"W3193863613","doi":"10.1186/s13148-021-01150-1","title":"Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging","year":2021,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; NOSM University; University of British Columbia; Impact; BC Children's Hospital; Health Sciences North","funders":"Institute of Aging; Canadian Institutes of Health Research; Government of Canada","keywords":"Epigenetics; Frailty Index; Gerontology; Demography; Healthy aging; Medicine; Longitudinal study; Biological age; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001689963,0.0001946571,0.000272533,0.00008505959,0.0001052205,0.00006439234,0.0001921758,0.0002499215,0.00002757448],"category_scores_gemma":[0.000886035,0.0001612014,0.00005904896,0.0003246804,0.0001209589,0.000002827981,0.00007751403,0.0003474148,0.000004216827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003235105,"about_ca_system_score_gemma":0.0002280329,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004764924,"about_ca_topic_score_gemma":0.5707136,"domain_scores_codex":[0.9975916,0.000698253,0.0005025925,0.0005905818,0.000244551,0.0003724241],"domain_scores_gemma":[0.9988633,0.0002521364,0.00009942151,0.0005084584,0.0001093839,0.0001673489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002609072,0.0004247084,0.9941684,0.000004658712,0.00003365033,0.0002346086,0.0004523763,0.00007455984,0.0002650204,0.00001601132,0.00002691549,0.004272984],"study_design_scores_gemma":[0.00125522,0.0009910414,0.9938765,0.00004281691,0.00003026797,0.000001536593,0.0002542044,0.0001538959,0.00175496,0.0001349467,0.001289859,0.0002147236],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966879,0.001464774,0.00009040213,0.0007819202,0.00009947302,0.000392018,0.00002714805,0.000003607452,0.0004527566],"genre_scores_gemma":[0.9969929,0.0009481278,0.0002302839,0.00141353,0.0001929874,0.00003672856,0.00009252943,0.00002729206,0.00006563459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5659487,"threshold_uncertainty_score":0.7203172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1744129746775886,"score_gpt":0.4069250684051434,"score_spread":0.2325120937275547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}