{"id":"W3193900524","doi":"10.1038/s41598-021-95986-5","title":"Rapid target validation in a Cas9-inducible hiPSC derived kidney model","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Ontario Research Foundation","keywords":"Computer science; Computational biology; CRISPR; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009124267,0.0005478045,0.000483832,0.0005269889,0.0004051441,0.0006022795,0.0006033835,0.000633151,0.0008498391],"category_scores_gemma":[0.0005128999,0.0002789714,0.0004808827,0.0002380248,0.0003848022,0.0003416945,0.0005301147,0.0008616121,0.000607062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004954562,"about_ca_system_score_gemma":0.0007317296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001925814,"about_ca_topic_score_gemma":0.001933484,"domain_scores_codex":[0.9993842,0.00006118131,0.00008214211,0.0001674897,0.0002587973,0.00004634652],"domain_scores_gemma":[0.999474,0.00008219644,0.0001156425,0.0001416195,0.0001210535,0.0000654625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002792368,0.00001757973,0.000144305,0.00003008399,0.000007831536,0.00009539772,0.00002502533,0.0004345498,0.9974636,0.000243723,0.00006876484,0.001441191],"study_design_scores_gemma":[0.000004462338,0.00007689392,0.0004418359,0.000004944476,0.00001546325,0.0002056888,0.00000913195,0.002207952,0.9949885,0.00005118792,0.001985024,0.000008772568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6586794,0.001074826,0.3291556,0.0002516599,0.000177243,0.0007206849,0.003030981,0.002633286,0.004276419],"genre_scores_gemma":[0.7855088,0.001478348,0.1997854,0.0001613659,0.00001592581,0.0006489601,0.003896104,0.0004526658,0.008052473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001925814,"threshold_uncertainty_score":0.004825413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440097630749896,"score_gpt":0.2410106162014443,"score_spread":0.2266096398939454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}