{"id":"W3193922103","doi":"10.1093/eurheartj/ehab499","title":"Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction","year":2021,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Daiichi Sankyo Europe; National Heart, Lung, and Blood Institute; Defense Acquisition Program Administration; Celladon Corporation; Medical Research Council; Japan Agency for Medical Research and Development; Otsuka Pharmaceutical; Amgen Astellas Biopharma; American Regent; Eli Lilly Japan; Chugai Pharmaceutical; Novartis Pharma; National Institutes of Health; Teijin Pharma; Svenska Läkaresällskapet; Pfizer Japan; Shionogi; Respicardia; MyoKardia; Bayer Yakuhin; British Heart Foundation; Ministry of Education, Culture, Sports, Science and Technology; Sanofi Pasteur; University of Oxford; Pfizer; Moderna; Mitsubishi Tanabe Pharma Corporation; National Medical Research Council; Boehringer Ingelheim Japan; University of Glasgow; Toa Eiyo; Kowa Company; Actelion Pharmaceuticals; Nippon Shinyaku; Nihon Medi-Physics; Japan Society for the Promotion of Science; Astellas Pharma; Cytokinetics; Ironwood Pharmaceuticals, Incorporated; Dainippon Sumitomo Pharma; Boston Scientific Corporation; Bristol-Myers Squibb; Ono Pharmaceutical; Eli Lilly and Company; Alnylam Pharmaceuticals; AstraZeneca; CSL Behring; Novo Nordisk; Gilead Sciences; Sanofi; LivaNova; GlaxoSmithKline; Amgen","keywords":"Medicine; Valsartan; Sacubitril; Blood pressure; Cardiology; Sacubitril, Valsartan; Internal medicine; Heart failure; Ejection fraction; Heart failure with preserved ejection fraction; Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001476553,0.0002990975,0.0009330142,0.0001737147,0.0001341887,0.0004283003,0.0002164151,0.0002713113,0.0008858881],"category_scores_gemma":[0.0009612303,0.00009780424,0.0007651026,0.0002027198,0.0002218134,0.0002481809,0.0001543444,0.0006853463,0.00007914839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423139,"about_ca_system_score_gemma":0.0004460704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004472389,"about_ca_topic_score_gemma":0.002396675,"domain_scores_codex":[0.9993755,0.000360322,0.00006206713,0.00006997593,0.00008733639,0.00004486035],"domain_scores_gemma":[0.9991233,0.0003030589,0.0002703048,0.0000476783,0.00004395381,0.0002117442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5842651,0.004854164,0.1624301,0.002721688,0.00885263,0.0006589519,0.0002311725,0.002165564,0.02496875,0.0006282039,0.003272306,0.2049513],"study_design_scores_gemma":[0.1678944,0.175705,0.6305971,0.0003447921,0.006427451,0.00126717,0.0001977835,0.004999394,0.005016327,0.0007474351,0.006738605,0.00006461795],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882895,0.009813759,0.000186965,0.0003142589,0.00007433177,0.00008215537,0.0001985143,0.0000170055,0.001023591],"genre_scores_gemma":[0.9975528,0.001297321,0.0003523245,0.0001994261,0.0001095631,0.00004170642,0.0002435675,0.000002014497,0.0002012995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476553,"threshold_uncertainty_score":0.007808864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545867216344335,"score_gpt":0.2774498846327851,"score_spread":0.2419912124693417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}