{"id":"W3193922103","doi":"10.1093/eurheartj/ehab499","title":"Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction","year":2021,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Daiichi Sankyo Europe; National Heart, Lung, and Blood Institute; Defense Acquisition Program Administration; Celladon Corporation; Medical Research Council; Japan Agency for Medical Research and Development; Otsuka Pharmaceutical; Amgen Astellas Biopharma; American Regent; Eli Lilly Japan; Chugai Pharmaceutical; Novartis Pharma; National Institutes of Health; Teijin Pharma; Svenska Läkaresällskapet; Pfizer Japan; Shionogi; Respicardia; MyoKardia; Bayer Yakuhin; British Heart Foundation; Ministry of Education, Culture, Sports, Science and Technology; Sanofi Pasteur; University of Oxford; Pfizer; Moderna; Mitsubishi Tanabe Pharma Corporation; National Medical Research Council; Boehringer Ingelheim Japan; University of Glasgow; Toa Eiyo; Kowa Company; Actelion Pharmaceuticals; Nippon Shinyaku; Nihon Medi-Physics; Japan Society for the Promotion of Science; Astellas Pharma; Cytokinetics; Ironwood Pharmaceuticals, Incorporated; Dainippon Sumitomo Pharma; Boston Scientific Corporation; Bristol-Myers Squibb; Ono Pharmaceutical; Eli Lilly and Company; Alnylam Pharmaceuticals; AstraZeneca; CSL Behring; Novo Nordisk; Gilead Sciences; Sanofi; LivaNova; GlaxoSmithKline; Amgen","keywords":"Medicine; Valsartan; Sacubitril; Blood pressure; Cardiology; Sacubitril, Valsartan; Internal medicine; Heart failure; Ejection fraction; Heart failure with preserved ejection fraction; Diabetes mellitus; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003047581,0.0001991355,0.0004053901,0.0001566307,0.0002172046,0.00009145253,0.00002234987,0.0000370503,0.00007147282],"category_scores_gemma":[0.00007166347,0.0001399692,0.0001031486,0.0001575296,0.00002131063,0.0001685042,0.00002662678,0.0001758862,0.00002636579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002443093,"about_ca_system_score_gemma":0.0000931194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002011465,"about_ca_topic_score_gemma":0.00006294381,"domain_scores_codex":[0.9985532,0.0002460231,0.0002961775,0.0003207242,0.0002981537,0.0002857407],"domain_scores_gemma":[0.9992448,0.00005297146,0.00007839056,0.0001997446,0.0002006167,0.0002234947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003638183,0.001916708,0.95888,0.00008754761,0.0002271666,0.0005636431,0.0001184776,0.00002375456,0.005107831,0.00002690573,0.02796638,0.001443401],"study_design_scores_gemma":[0.009078916,0.003770144,0.6913563,0.0003095839,0.0001876291,0.0002333856,0.0002942311,0.00004692617,0.000907681,0.000011526,0.29366,0.000143714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990912,0.0002764322,0.0001308684,0.007269792,0.0001202746,0.0008464868,0.000004655441,0.00003560299,0.0004039509],"genre_scores_gemma":[0.9921541,0.00008778651,0.006027166,0.0004498498,0.0002405761,0.00001867462,0.00006144466,0.00004500505,0.0009154642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2675237,"threshold_uncertainty_score":0.5707777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03545867216344335,"score_gpt":0.2774498846327851,"score_spread":0.2419912124693417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}