{"id":"W3193967810","doi":"10.48336/g6k6-7244","title":"Genomic and functional analyses of Newfoundland and Labrador families with intracranial aneurysms","year":2021,"lang":"en","type":"dissertation","venue":"Memorial University Research Repository (Memorial University)","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Heart and Stroke Foundation of Canada","keywords":"Sanger sequencing; Zebrafish; Morpholino; Biology; Danio; Phenotype; Exome sequencing; Genetics; Candidate gene; Gene; Exome; Population; Gene knockdown; Mutant; Bioinformatics; Mutation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237501,0.000373356,0.0002679527,0.001868393,0.001031601,0.0004932692,0.0004057103,0.0002614243,0.003611081],"category_scores_gemma":[0.0007577412,0.0001845024,0.000372065,0.001687175,0.0004111994,0.0001260553,0.0005896678,0.0002477119,0.0003866966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001929161,"about_ca_system_score_gemma":0.001130965,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3932334,"about_ca_topic_score_gemma":0.5184622,"domain_scores_codex":[0.9996588,0.00003891956,0.00002746742,0.0001128218,0.00005274255,0.0001092597],"domain_scores_gemma":[0.9996077,0.00008250715,0.0001168112,0.00003984911,0.00006761206,0.00008561536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007939088,0.0001217536,0.9229186,0.00007679977,0.0002152909,0.01239174,0.003917349,0.0004792055,0.03131482,0.0004184387,0.002768449,0.02458368],"study_design_scores_gemma":[0.000007292557,0.0000256546,0.9952288,0.0000122023,0.00003367584,0.002146894,0.0006004029,0.00006788022,0.0004396715,0.00001279958,0.001419203,0.000005605129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957063,0.0002390247,0.0001138804,0.00009263316,0.000003849602,0.00001008661,0.002143059,0.000008169871,0.001683125],"genre_scores_gemma":[0.9934406,0.0004324805,0.0005133962,0.0000894304,0.000006911196,0.00002838899,0.003388386,0.0000125069,0.002088031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6067666,"threshold_uncertainty_score":0.7818891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03089671990364393,"score_gpt":0.2741874065796765,"score_spread":0.2432906866760326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}