{"id":"W3194050383","doi":"10.1101/2021.08.22.457269","title":"FEDERATED MORPHOMETRY FEATURE SELECTION FOR HIPPOCAMPAL MORPHOMETRY ASSOCIATED BETA-AMYLOID AND TAU PATHOLOGY","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Hippocampal formation; Subiculum; Neuroscience; Atrophy; Neuroimaging; Hippocampus; Magnetic resonance imaging; Psychology; Alzheimer's Disease Neuroimaging Initiative; Voxel-based morphometry; Medicine; Pathology; Internal medicine; Cognition; Cognitive impairment; White matter; Dentate gyrus; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001893346,0.001291681,0.001433902,0.0009831501,0.0004064809,0.0007702443,0.00115014,0.001107823,0.001801813],"category_scores_gemma":[0.004279468,0.0002606073,0.00139869,0.0005906406,0.0005182064,0.0004919023,0.0006952013,0.0009814515,0.0005462111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004300356,"about_ca_system_score_gemma":0.0009980948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005304455,"about_ca_topic_score_gemma":0.004296048,"domain_scores_codex":[0.9993479,0.0002056694,0.0000397253,0.0001935729,0.0001247705,0.00008845552],"domain_scores_gemma":[0.9985355,0.0006884629,0.0001212062,0.0001688061,0.0004098069,0.00007625555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009997424,0.0006058351,0.0134156,0.0001655923,0.0004050326,0.0004324111,0.0001115783,0.5561056,0.01459782,0.001386033,0.01006329,0.4017116],"study_design_scores_gemma":[0.00001952914,0.00005619078,0.000961762,0.000005222849,0.00001666515,0.00003369998,0.00001171374,0.9970353,0.001114811,0.0005503959,0.00018944,0.000005320206],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2320062,0.0009867902,0.7588819,0.0006383058,0.0001772882,0.0001818757,0.0007158401,0.005243188,0.001168511],"genre_scores_gemma":[0.8533517,0.0001526286,0.1413876,0.0002637562,0.0001025638,0.0001928685,0.002235279,0.0001675619,0.002146102],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005304455,"threshold_uncertainty_score":0.01054716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048684376026617,"score_gpt":0.2670819469888963,"score_spread":0.2465951032286301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}