{"id":"W3194096467","doi":"10.3390/curroncol28050284","title":"Reflex ROS1 IHC Screening with FISH Confirmation for Advanced Non-Small Cell Lung Cancer—A Cost-Efficient Strategy in a Public Healthcare System","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Reflex; KRAS; Biomarker; Lung cancer; Guideline; Fluorescence in situ hybridization; ROS1; Cancer; Population; Oncology; Internal medicine; Pathology; Adenocarcinoma; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783123,0.0001837968,0.0002921772,0.00006234822,0.00009472094,0.00004299985,0.0001424521,0.0001744388,0.000005694486],"category_scores_gemma":[0.00004009179,0.0001896284,0.00006572463,0.0001584882,0.00003824221,0.000004168504,0.00008569819,0.00015839,7.301456e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003420089,"about_ca_system_score_gemma":0.001364607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006590403,"about_ca_topic_score_gemma":0.003997587,"domain_scores_codex":[0.9985688,0.00007913482,0.0003467417,0.0004836902,0.00008868061,0.0004329173],"domain_scores_gemma":[0.9988955,0.00005572639,0.0002139642,0.0002619747,0.0004294651,0.0001433254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002891363,0.002635933,0.07194775,0.007594997,0.0003052427,0.0001522201,0.001434718,0.1586983,0.129019,0.004676031,0.01544295,0.6052015],"study_design_scores_gemma":[0.02462513,0.004387575,0.01493807,0.001305041,0.0002466843,0.0001169869,0.007890236,0.103496,0.1153268,0.00002240677,0.7258357,0.001809325],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565374,0.008735876,0.02979726,0.001141639,0.0009728865,0.001644501,0.0004707986,0.00001966154,0.0006799467],"genre_scores_gemma":[0.9956845,0.0009459865,0.0008106456,0.0002634653,0.0002663087,0.0009297871,0.001030873,0.00002920155,0.00003924571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7103928,"threshold_uncertainty_score":0.7732821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0715834885082691,"score_gpt":0.3749076231805532,"score_spread":0.3033241346722841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}