{"id":"W3194121618","doi":"10.1021/acscentsci.1c00525","title":"Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells","year":2021,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"CD28; Effector; CD80; Sialic acid; Cell biology; Chemistry; Immune system; T cell; Biology; Biochemistry; Immunology; Cytotoxic T cell; CD40; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338351,0.00005684143,0.0001152105,0.00005361083,0.00008485912,0.000008701143,0.0001447369,0.00006183373,0.000793873],"category_scores_gemma":[0.00009950482,0.00005153232,0.00004153219,0.0003087117,0.0002998852,0.0002048966,0.00005329969,0.0000833779,0.00005003715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002687499,"about_ca_system_score_gemma":0.0001041572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003524186,"about_ca_topic_score_gemma":0.000002906142,"domain_scores_codex":[0.9993492,0.00003140776,0.0002039357,0.0001561486,0.00005137429,0.0002079583],"domain_scores_gemma":[0.9994823,0.00003653482,0.0001113124,0.0001653995,0.000189175,0.00001531034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004129993,0.0000585604,0.001411818,0.000007235908,0.000008615372,4.528053e-7,0.0002629361,0.0000996105,0.9960551,0.0003386858,0.0007714104,0.0009443352],"study_design_scores_gemma":[0.0002944107,0.00005963263,0.01925622,0.0000171932,0.000009922876,0.00000912554,0.000147402,0.00005208336,0.9760421,0.00001311852,0.004049691,0.00004907658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945846,0.0003296867,0.0002246779,0.00007306605,0.003104304,0.00005537382,0.000003851609,0.00001107019,0.001613406],"genre_scores_gemma":[0.9984176,0.00005342031,0.00002555668,0.00005376044,0.00001002297,7.874992e-7,0.00002193016,0.00000249205,0.001414427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02001292,"threshold_uncertainty_score":0.8692353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009851683002969618,"score_gpt":0.2373338061839598,"score_spread":0.2274821231809902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}