{"id":"W3194144951","doi":"10.1093/jac/dkab279","title":"Investigation of mechanisms responsible for decreased susceptibility of aztreonam/avibactam activity in clinical isolates of Enterobacterales collected in Europe, Asia and Latin America in 2019","year":2021,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Aztreonam; Enterobacter cloacae; Klebsiella pneumoniae; Microbiology; Avibactam; Biology; Escherichia coli; Carbapenem; Antibiotic resistance; Antibiotics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006531148,0.0001201328,0.0005469864,0.0001364075,0.000008354931,0.000007504689,0.0001166408,0.0001502831,0.000007542208],"category_scores_gemma":[0.0004832913,0.0001174346,0.0001058174,0.0003607367,0.0001723284,0.00001619815,0.00003083253,0.0001271908,3.866786e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002019526,"about_ca_system_score_gemma":0.0004693591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004643631,"about_ca_topic_score_gemma":0.0004934263,"domain_scores_codex":[0.9982761,0.0003413904,0.000976986,0.000201634,0.00007296244,0.0001309651],"domain_scores_gemma":[0.9984607,0.000138445,0.0008295297,0.0001685158,0.0003638851,0.00003900053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003920184,0.0002376155,0.2708918,0.00007093427,0.00002883006,0.00000237777,0.00007185869,0.000009585535,0.7244052,0.000004489785,0.00009251721,0.0002646295],"study_design_scores_gemma":[0.001896779,0.0003945986,0.4141037,0.0001730771,0.000005691316,0.000004761671,0.00002458119,0.00002792174,0.5832441,0.0000407706,0.00003024823,0.00005379444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988807,0.00007034007,0.0005140528,0.0002468426,0.00005219376,0.0001898896,0.00003776404,8.399761e-7,0.00000736935],"genre_scores_gemma":[0.9835581,0.0009032949,0.01539374,0.00006465535,0.00001832243,3.890238e-7,0.00001933896,0.00001471412,0.00002746966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1432119,"threshold_uncertainty_score":0.4788845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01544872357367875,"score_gpt":0.2809088414269172,"score_spread":0.2654601178532385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}