{"id":"W3194148012","doi":"10.1016/j.ajo.2021.08.009","title":"Challenges of Cost-Effectiveness Analyses of Novel Therapeutics for Inherited Retinal Diseases","year":2021,"lang":"en","type":"review","venue":"American Journal of Ophthalmology","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kellogg's (Canada)","funders":"National Center for Advancing Translational Sciences; National Eye Institute; National Institutes of Health","keywords":"Retinal; Optometry; Medicine; Computational biology; Ophthalmology; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0431085,0.001424122,0.007554538,0.003397179,0.0002953215,0.004400057,0.002744955,0.002680103,0.005368266],"category_scores_gemma":[0.1145287,0.0007127366,0.004915691,0.003618196,0.001425878,0.004383302,0.001573727,0.005914839,0.0004989086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004501041,"about_ca_system_score_gemma":0.00779238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004348175,"about_ca_topic_score_gemma":0.007602383,"domain_scores_codex":[0.9739267,0.01953331,0.002094765,0.000590075,0.003499448,0.0003556779],"domain_scores_gemma":[0.8312805,0.1576611,0.004380433,0.0009831628,0.005194281,0.0005005143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008166562,0.0001218325,0.0006460659,0.05417536,0.009100539,0.0001026782,0.00008375233,0.0071771,0.0001472916,0.03439923,0.01816687,0.8750626],"study_design_scores_gemma":[0.001947121,0.001111979,0.00874528,0.2746177,0.03852019,0.001181053,0.0006309992,0.0128259,0.0006369193,0.2387993,0.4207394,0.0002441025],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001919839,0.9955995,0.0007183987,0.002805651,0.0001567805,0.0000168741,0.00005337736,0.000004664827,0.0004527975],"genre_scores_gemma":[0.01465735,0.9790029,0.002912778,0.001973306,0.001052118,0.00009567319,0.0001068025,0.00001442248,0.0001846192],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0431085,"threshold_uncertainty_score":0.2279823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.76280625146455,"score_gpt":0.5860152206182264,"score_spread":0.1767910308463235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}