{"id":"W3194157976","doi":"10.1016/j.jtct.2021.08.007","title":"Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improve Transplantation Outcomes in Older Patients with Myelodysplastic Syndromes","year":2021,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; National Heart, Lung, and Blood Institute; U.S. Public Health Service; Health Resources and Services Administration; CytoSen Therapeutics; Kiadis Pharma; Pfizer; Incyte; Kyowa Kirin Pharmaceutical Development; Jazz Pharmaceuticals; Medical College of Wisconsin; Takeda Pharmaceuticals U.S.A.; Meso Scale Diagnostics; AbbVie; National Cancer Institute; Gilead Sciences; Karyopharm Therapeutics; Celgene; Novartis; GlaxoSmithKline; Otsuka America; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Roche; Astellas Pharma US; Falk Foundation; CareDx; Daiichi-Sankyo","keywords":"Medicine; Fludarabine; Busulfan; Melphalan; Alemtuzumab; Internal medicine; Transplantation; Regimen; Hematopoietic stem cell transplantation; Cumulative incidence; Incidence (geometry); Surgery; Gastroenterology; Oncology; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001234766,0.0002420425,0.0005047974,0.0001864408,0.00006292712,0.00002747991,0.00003975033,0.00008338458,0.00003549747],"category_scores_gemma":[0.000005326668,0.0001696988,0.0000249954,0.000238073,0.0001822443,0.0001449708,0.000004321655,0.0001777406,5.1889e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002528081,"about_ca_system_score_gemma":0.0001076905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000797422,"about_ca_topic_score_gemma":0.00009254855,"domain_scores_codex":[0.9986408,0.00009648408,0.000319714,0.0003803438,0.0003357922,0.0002268389],"domain_scores_gemma":[0.9993521,0.0001315674,0.00008270712,0.0001490612,0.0001496788,0.0001348839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01036458,0.0005947738,0.630441,0.001696384,0.0003961203,0.0005709264,0.00701294,0.00001839225,0.3432226,0.00009196906,0.000003371647,0.005586884],"study_design_scores_gemma":[0.02601505,0.0009524517,0.8310705,0.0003430012,0.0001849292,0.000203059,0.0003892428,0.0001789015,0.1404332,0.00001601996,0.000007843891,0.0002058029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974103,0.0006743775,0.000656653,0.0003707172,0.00002152413,0.000678829,0.00009272002,0.00002395888,0.00007094211],"genre_scores_gemma":[0.9944043,0.00393739,0.0007651353,0.00009192858,0.000009132086,0.00002854323,0.0006221629,0.00003160297,0.0001097833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2027894,"threshold_uncertainty_score":0.6920117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111338953044004,"score_gpt":0.245643071941076,"score_spread":0.234529682410636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}