{"id":"W3194238275","doi":"10.1126/scisignal.abe2606","title":"Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function","year":2021,"lang":"en","type":"article","venue":"Science Signaling","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Lorentz Center; University of Washington; Fred Hutchinson Cancer Research Center; National Multiple Sclerosis Society Michigan Chapter; Takeda Canada; American Cancer Society","keywords":"T-cell receptor; Chimeric antigen receptor; Antigen; T cell; CD3; Biology; Cancer research; Cell biology; Immunology; Immune system; CD8","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004489519,0.0003688317,0.0002209901,0.000248281,0.0001257991,0.0005480124,0.0002248739,0.0003721378,0.001478892],"category_scores_gemma":[0.000355074,0.0001823045,0.0001999978,0.0001846044,0.0002073897,0.0003940745,0.0001314171,0.0005539519,0.0002993191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005215888,"about_ca_system_score_gemma":0.0002710223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000307543,"about_ca_topic_score_gemma":0.0003896154,"domain_scores_codex":[0.9996922,0.00005823527,0.00001944141,0.00005545345,0.00008000663,0.00009475885],"domain_scores_gemma":[0.9998337,0.00004503685,0.00004028382,0.00001854982,0.00003386277,0.00002858736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004218,0.00004525212,0.0001802789,0.00002637726,0.000005094433,0.00001836662,0.000009463395,0.0006937087,0.9959519,0.0005107052,0.00002649601,0.00233198],"study_design_scores_gemma":[0.0000132629,0.0004691068,0.0005898277,0.000002388521,0.00001698371,0.00008135179,0.00001183036,0.002257244,0.9951228,0.0000835902,0.001348394,0.00000318247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775158,0.001429587,0.01780873,0.0001083466,0.00001667271,0.00004696966,0.0002948291,0.00008841963,0.002690674],"genre_scores_gemma":[0.9925886,0.0008346337,0.005016615,0.00005019469,0.000004898526,0.00004488768,0.0003400077,0.00002655867,0.001093589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478892,"threshold_uncertainty_score":0.004947364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04897694173428213,"score_gpt":0.3258920534028814,"score_spread":0.2769151116685992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}