{"id":"W3194271572","doi":"10.18433/jpps31839","title":"Synthesis of New Hybrid Derivatives from Metronidazole and Eugenol Analogues as Trypanocidal Agents","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Benznidazole; Trypanosoma cruzi; Chemistry; Nifurtimox; Chagas disease; Context (archaeology); Combinatorial chemistry; Drug discovery; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007243916,0.0002829063,0.0002000642,0.0002345454,0.00009904358,0.0002756988,0.0002506461,0.0002998881,0.002827717],"category_scores_gemma":[0.0001058275,0.00009630754,0.0002816256,0.0002821831,0.0001028653,0.0003406192,0.0002113853,0.0003439191,0.0005411895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001606022,"about_ca_system_score_gemma":0.00007730591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001898204,"about_ca_topic_score_gemma":0.0004862714,"domain_scores_codex":[0.9999491,0.000006817469,0.000005363334,0.00001166638,0.00001249859,0.00001455553],"domain_scores_gemma":[0.9999636,0.00000536018,0.00001109441,0.0000046813,0.000006569359,0.000008619085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001263648,0.0000530004,0.0001852641,0.0002849033,0.00002303,0.0002278987,0.00005570128,0.0006294574,0.9870573,0.0006310999,0.00008844581,0.01063744],"study_design_scores_gemma":[0.00006632196,0.001467173,0.0025807,0.00004826416,0.00008589251,0.0005336441,0.00006916033,0.001102282,0.9733928,0.0002110524,0.02041786,0.00002487584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589191,0.009645293,0.01892469,0.000190433,0.00009867529,0.0001865185,0.0008279874,0.0001849361,0.0110224],"genre_scores_gemma":[0.9805923,0.003347544,0.01197712,0.00006474942,0.00001305725,0.00005174784,0.0004419776,0.00002295245,0.003488552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002827717,"threshold_uncertainty_score":0.009459615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308688005827424,"score_gpt":0.4483510280906636,"score_spread":0.3174822275079212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}