{"id":"W3194279396","doi":"10.1002/acn3.51441","title":"Gut microbiome is associated with multiple sclerosis activity in children","year":2021,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Multiple Sclerosis Society; National Multiple Sclerosis Society","keywords":"Hazard ratio; Confidence interval; Medicine; Microbiome; Multiple sclerosis; Clinically isolated syndrome; Proportional hazards model; Internal medicine; Metagenomics; Bioinformatics; Immunology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380596,0.00009045588,0.0002586449,0.00002866736,0.00003126034,0.00000410117,0.00005479816,0.0002212889,0.00002011389],"category_scores_gemma":[0.00008770148,0.00008225776,0.00008592087,0.00009023823,0.0001807745,0.000004242382,0.00002374528,0.0001598774,0.000001140886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":1.112832e-7,"about_ca_system_score_gemma":0.0001089851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002626964,"about_ca_topic_score_gemma":0.0002859506,"domain_scores_codex":[0.9989579,0.0001820555,0.0003170572,0.0003219056,0.00005531005,0.0001658145],"domain_scores_gemma":[0.9995081,0.0001217436,0.00009581892,0.0001115871,0.0001018917,0.00006084105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004479598,0.0003144106,0.9087341,0.000006187763,0.00007779812,0.000002807125,0.00001053591,0.000009107953,0.0884373,0.00002259658,0.0001572708,0.001779914],"study_design_scores_gemma":[0.001537461,0.0003235335,0.9849981,0.000009501454,0.000008984911,0.00001532566,5.518027e-7,0.00001911687,0.01227248,0.0001019955,0.000634761,0.00007819766],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927541,0.0003089922,0.00002901476,0.006582497,0.00002973477,0.00008209101,0.0001556647,0.000002944643,0.00005498408],"genre_scores_gemma":[0.9949185,0.000664929,0.00007885632,0.004097283,0.00004379222,0.000002139455,0.0001553725,0.000008004145,0.00003108887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07626398,"threshold_uncertainty_score":0.3354374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09006425603607471,"score_gpt":0.3494235452085842,"score_spread":0.2593592891725095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}