{"id":"W3194282836","doi":"10.1016/j.ajhg.2021.07.013","title":"Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression","year":2021,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Children's Hospital of Eastern Ontario","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; AstraZeneca; Shire; Crohn's and Colitis Foundation; Leona M. and Harry B. Helmsley Charitable Trust; AbbVie; Genentech; Medical Research Council; Celgene; Janssen Pharmaceuticals; Gilead Sciences; Cedars-Sinai Medical Center; Takeda Pharmaceuticals U.S.A.; School of Public Health, University of California Berkeley; Pfizer","keywords":"Genome-wide association study; Colectomy; Gene expression profiling; Expression quantitative trait loci; Ulcerative colitis; Disease; Transcriptome; Cohort; Population; Quantitative trait locus; Biology; Gene expression; Medicine; Gene; Bioinformatics; Oncology; Internal medicine; Genetics; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005122589,0.0002566139,0.0002973409,0.0005856086,0.0002160728,0.0007138831,0.0002105395,0.0004646713,0.0007778135],"category_scores_gemma":[0.001602454,0.0001478564,0.0003030826,0.0004590442,0.0002992532,0.0002189256,0.0002163703,0.0005779152,0.0001871375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086607,"about_ca_system_score_gemma":0.0001678919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009547363,"about_ca_topic_score_gemma":0.001170511,"domain_scores_codex":[0.9996687,0.0001541976,0.00001586428,0.00007135014,0.00004416142,0.00004563906],"domain_scores_gemma":[0.9991596,0.0004493626,0.0001684856,0.00004930806,0.00006275842,0.0001104398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001155887,0.00006387769,0.9904693,0.000009514984,0.00008796185,0.00006243689,0.00003398849,0.0003878808,0.004428292,0.00004374247,0.00006386233,0.003193321],"study_design_scores_gemma":[0.00001350596,0.0001804217,0.9956776,0.000004271434,0.00006300204,0.0001566691,0.0000525739,0.00273095,0.0008740059,0.0001273111,0.0001135501,0.00000601319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989383,0.0002211586,0.0003034149,0.00005046566,0.000008480202,0.000003334891,0.0001738221,0.000007003934,0.0002939758],"genre_scores_gemma":[0.9993286,0.00005922508,0.0002619588,0.00001755934,0.00001148211,0.000004004051,0.0001444172,0.000002970806,0.0001699377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009547363,"threshold_uncertainty_score":0.002709091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00793533422363594,"score_gpt":0.2688521505964718,"score_spread":0.2609168163728359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}