{"id":"W3194295390","doi":"10.1111/acer.14670","title":"Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta‐regression analysis to develop an enrichment strategy","year":2021,"lang":"en","type":"review","venue":"Alcoholism Clinical and Experimental Research","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Centre for Addiction and Mental Health","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Placebo; Abstinence; Interquartile range; Medicine; Internal medicine; Population; Randomized controlled trial; Meta-analysis; Severity of illness; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.256557,0.0005182155,0.005067815,0.000757621,0.0003302524,0.0002327136,0.0007031519,0.000595758,0.0001126242],"category_scores_gemma":[0.1128317,0.0002855101,0.001363369,0.002631987,0.001026907,0.0002027673,0.0009939288,0.001292391,0.000007102919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006572937,"about_ca_system_score_gemma":0.0005280132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001242099,"about_ca_topic_score_gemma":0.00003336573,"domain_scores_codex":[0.8624735,0.1294746,0.004114046,0.001931249,0.00130827,0.0006983035],"domain_scores_gemma":[0.8613683,0.136672,0.0005854437,0.0007085931,0.0002029704,0.000462661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03403546,0.001683975,0.0003083406,0.001401128,0.004055477,0.00009896977,0.0004710077,0.00002298576,0.0003432578,0.0008788332,0.001372922,0.9553276],"study_design_scores_gemma":[0.04362324,0.009867376,0.002459657,0.007840576,0.03380573,0.00006407565,0.002826321,0.03561566,0.004713775,0.001011377,0.8553133,0.002858897],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02580486,0.962536,0.0006210688,0.0004106508,0.0003772947,0.009653894,0.0004509002,0.00003295256,0.000112319],"genre_scores_gemma":[0.05867998,0.9378781,0.0003528145,0.0002273713,0.0002534683,0.002065089,0.0001140671,0.00003572325,0.0003934132],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9524688,"threshold_uncertainty_score":0.9999597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6973427694790598,"score_gpt":0.6262728593097647,"score_spread":0.07106991016929509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}