{"id":"W3194367373","doi":"10.1016/j.jaad.2021.06.329","title":"25934 Bimekizumab efficacy for moderate to severe plaque psoriasis across patient subgroups: Pooled results from 3 multicenter, randomized, double-blinded phase 3 trials","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Queen's University","funders":"","keywords":"Medicine; Plaque psoriasis; Psoriasis; Randomized controlled trial; Multicenter study; Internal medicine; Double blinded; Severity of illness; Dermatology; Surgery; Pathology; Placebo; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007113971,0.002183553,0.006876949,0.0006599904,0.0006103843,0.002029051,0.0007792595,0.001967623,0.00352009],"category_scores_gemma":[0.006485467,0.0009760407,0.008679583,0.0008492113,0.0008668615,0.001385181,0.0006397811,0.002593894,0.0004821185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000671028,"about_ca_system_score_gemma":0.0009493559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007096786,"about_ca_topic_score_gemma":0.001869112,"domain_scores_codex":[0.9969226,0.001843465,0.0003387345,0.0004405487,0.0002229428,0.0002317865],"domain_scores_gemma":[0.9975246,0.001180723,0.0006773972,0.000222014,0.0001778195,0.0002174936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9147677,0.001176336,0.002343641,0.004845077,0.04193554,0.00005191585,0.00007482801,0.0006938314,0.002616461,0.0001300948,0.001432111,0.02993244],"study_design_scores_gemma":[0.9207477,0.03016895,0.009498235,0.0003999951,0.03590178,0.00009937953,0.00006594408,0.0005308338,0.0005659234,0.0004991585,0.001457463,0.00006460321],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8363695,0.1431772,0.004440721,0.001363806,0.001741337,0.005077318,0.003058179,0.0003444414,0.004427538],"genre_scores_gemma":[0.9765646,0.01472366,0.002178266,0.001367249,0.0006224947,0.002148059,0.001349171,0.00005258412,0.0009940056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007113971,"threshold_uncertainty_score":0.03762275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05329753619340438,"score_gpt":0.3557059412527911,"score_spread":0.3024084050593867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}