{"id":"W3194367680","doi":"10.1182/bloodadvances.2020003844","title":"Tisagenlecleucel immunogenicity in relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital","funders":"","keywords":"Cytokine release syndrome; Immunogenicity; Antibody; Immunology; Medicine; Diffuse large B-cell lymphoma; Lymphoma; Internal medicine; B cell; Immunotherapy; Immune system; Oncology; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001072377,0.000149073,0.0004642148,0.0002046745,0.000087929,0.000320912,0.0001655083,0.0002329505,0.0009849792],"category_scores_gemma":[0.0006601196,0.0001161229,0.0002713284,0.0002727513,0.000245865,0.0002698239,0.000170463,0.0004886823,0.0002163967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379773,"about_ca_system_score_gemma":0.0003240547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000396503,"about_ca_topic_score_gemma":0.000953708,"domain_scores_codex":[0.9996225,0.0001943878,0.0000297061,0.00003042332,0.00007855349,0.00004452402],"domain_scores_gemma":[0.999608,0.00009844699,0.0001407592,0.00002444857,0.00002746165,0.0001010596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1934537,0.01044825,0.2208621,0.001484275,0.001302363,0.001262816,0.0004543602,0.002526385,0.1715962,0.0006676338,0.004607409,0.3913345],"study_design_scores_gemma":[0.02734761,0.2923184,0.6244161,0.0001491767,0.0009324001,0.003262914,0.0003551388,0.003756663,0.02766249,0.0004651682,0.01927995,0.00005403519],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971096,0.001859399,0.00008326815,0.0000674539,0.00001231023,0.00005342581,0.00009158196,0.00001123776,0.0007117218],"genre_scores_gemma":[0.9986223,0.0005470234,0.0001133461,0.0001330857,0.00001745443,0.00004916175,0.000301548,0.000003409883,0.000212621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072377,"threshold_uncertainty_score":0.005671322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010605702794143,"score_gpt":0.2702827667122035,"score_spread":0.2601767096842621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}