{"id":"W3194367680","doi":"10.1182/bloodadvances.2020003844","title":"Tisagenlecleucel immunogenicity in relapsed/refractory acute lymphoblastic leukemia and diffuse large B-cell lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Hospital","funders":"","keywords":"Cytokine release syndrome; Immunogenicity; Antibody; Immunology; Medicine; Diffuse large B-cell lymphoma; Lymphoma; Internal medicine; B cell; Immunotherapy; Immune system; Oncology; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002351789,0.0002649404,0.0004944768,0.0001520757,0.000110754,0.00004344496,0.0001506819,0.0001533753,0.0005786577],"category_scores_gemma":[0.0001444625,0.0002520419,0.0001207595,0.0004553888,0.0001307627,0.0001762536,0.0001890004,0.0002598375,0.00005558238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844141,"about_ca_system_score_gemma":0.0005805511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004896283,"about_ca_topic_score_gemma":0.0001638211,"domain_scores_codex":[0.9978502,0.000125245,0.0003727296,0.0005827186,0.0004490577,0.0006200357],"domain_scores_gemma":[0.9987857,0.0002610792,0.00008627723,0.000536494,0.000104335,0.0002260816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001018589,0.005794332,0.02520882,0.0002986942,0.0002787985,0.003350074,0.0006162485,0.000004406858,0.9236744,0.00006371919,0.0001261235,0.03956577],"study_design_scores_gemma":[0.1217713,0.001306495,0.09718622,0.0004893205,0.0006339477,0.001693258,0.001028377,0.0005003263,0.6543931,0.0004602208,0.1196041,0.0009333817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611093,0.03364602,0.00002535039,0.0001025195,0.0001590261,0.0002831459,0.00003496064,0.00006607326,0.004573553],"genre_scores_gemma":[0.9714235,0.01359746,0.0005843472,0.0003792826,0.0001375827,0.00004054303,0.00003919113,0.00005982714,0.01373825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2692814,"threshold_uncertainty_score":0.9999932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010605702794143,"score_gpt":0.2702827667122035,"score_spread":0.2601767096842621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}