{"id":"W3194415632","doi":"10.1136/gutjnl-2021-324420","title":"Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); University Health Network","funders":"National Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; National Research Foundation Singapore; Duke-NUS Medical School","keywords":"Immune system; Immunotherapy; Cancer research; Tumor microenvironment; Immune checkpoint; Biology; Cancer; Epigenetics; Cancer immunotherapy; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002427213,0.0001424058,0.0002154994,0.0002522024,0.00005932605,0.0003421716,0.0001283504,0.0002099469,0.001092664],"category_scores_gemma":[0.0005572761,0.0001299059,0.0001628645,0.0002026947,0.000181719,0.0001365384,0.0002331047,0.0002988085,0.0002005545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001627203,"about_ca_system_score_gemma":0.0001063234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002619924,"about_ca_topic_score_gemma":0.0003875495,"domain_scores_codex":[0.99985,0.00002343323,0.00001001806,0.00004927066,0.00004361469,0.0000236548],"domain_scores_gemma":[0.9996985,0.0000586077,0.0001568498,0.00002803898,0.00002334363,0.00003466403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007499686,0.00002676698,0.03239037,0.00009362832,0.00003504947,0.0001045137,0.00006220725,0.0007967767,0.9532551,0.0001089725,0.00006297783,0.01231362],"study_design_scores_gemma":[0.00004530585,0.001183213,0.5248834,0.00003101609,0.0001236738,0.002134724,0.0001855873,0.008364953,0.4584289,0.0003995067,0.004197603,0.00002209316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968335,0.0009131114,0.00161597,0.00002488504,0.000003632073,0.000008873238,0.000241554,0.00005338667,0.0003050738],"genre_scores_gemma":[0.998157,0.000225438,0.001004982,0.00002230898,0.000002768562,0.0000140688,0.0002297549,0.0000163698,0.0003273236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092664,"threshold_uncertainty_score":0.003655374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435740946988463,"score_gpt":0.266643565983083,"score_spread":0.2522861565131984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}