{"id":"W3194415632","doi":"10.1136/gutjnl-2021-324420","title":"Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition","year":2021,"lang":"en","type":"article","venue":"Gut","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); University Health Network","funders":"National Medical Research Council; Associazione Italiana per la Ricerca sul Cancro; National Research Foundation Singapore; Duke-NUS Medical School","keywords":"Immune system; Immunotherapy; Cancer research; Tumor microenvironment; Immune checkpoint; Biology; Cancer; Epigenetics; Cancer immunotherapy; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178985,0.00009139731,0.0001699885,0.00007480392,0.00006643709,0.00003354004,0.00002320923,0.00004388025,0.0001258523],"category_scores_gemma":[0.00007955873,0.00008982619,0.00005036052,0.0002437865,0.00003005318,0.00005573678,0.00003093247,0.0001099744,0.00001431666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008613702,"about_ca_system_score_gemma":0.00007960249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000818499,"about_ca_topic_score_gemma":0.0004695212,"domain_scores_codex":[0.9991338,0.00003864558,0.0003304793,0.0002120878,0.000113974,0.0001710262],"domain_scores_gemma":[0.9996397,0.00001785034,0.00004873924,0.0001808991,0.00006473744,0.0000480603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00023026,0.00005663517,0.0006970509,0.00007285598,0.00001709424,0.00007931578,0.001001383,0.000001275832,0.9946731,0.00003964326,0.0001062455,0.003025121],"study_design_scores_gemma":[0.002194192,0.000122196,0.3657951,0.001059505,0.00002218734,0.00008642413,0.0005159377,0.00003269448,0.6250904,0.0002704904,0.00464794,0.0001629227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841674,0.00413918,0.0002390719,0.009088908,0.0001342312,0.0003037239,0.000007504086,0.00002207922,0.001897875],"genre_scores_gemma":[0.9952832,0.0001438761,0.001942851,0.0004800056,0.00012676,0.00004732921,0.00003686542,0.00001400331,0.001925036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3695827,"threshold_uncertainty_score":0.3663006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435740946988463,"score_gpt":0.266643565983083,"score_spread":0.2522861565131984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}