{"id":"W3194418941","doi":"10.1021/acsabm.1c00431","title":"Visible Fluorescent Light-up Probe for DNA Three-Way Junctions Provides Host–Guest Biosensing Applications","year":2021,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Fluorescence; DNA; Biosensor; Chemistry; Biophysics; Combinatorial chemistry; Biochemistry; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001834367,0.0003729671,0.000228044,0.0001400943,0.0001420571,0.0002777149,0.0002745368,0.0006873515,0.001269992],"category_scores_gemma":[0.0001647731,0.0001653541,0.0002409326,0.0001093962,0.0002428875,0.0002909764,0.0003339502,0.0006690411,0.0006295063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424473,"about_ca_system_score_gemma":0.000122454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001421734,"about_ca_topic_score_gemma":0.0002556325,"domain_scores_codex":[0.9998273,0.00003321133,0.000006483388,0.00004616059,0.00004682352,0.00004000958],"domain_scores_gemma":[0.999892,0.0000316869,0.00002635833,0.00001121035,0.00001284513,0.00002583774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000165844,0.000008552222,0.00005730708,0.00002431343,0.000001965108,0.00002669501,0.0000113553,0.00003347663,0.9986255,0.000134819,0.00003333508,0.001026096],"study_design_scores_gemma":[0.000001228526,0.00003900296,0.000154497,8.267399e-7,0.000001561345,0.00005618146,0.000003913768,0.0003791102,0.9986808,0.00001752355,0.0006635573,0.000001897463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9222936,0.003302745,0.06926858,0.0003164709,0.000084117,0.0000593295,0.0001846716,0.0005503808,0.003940147],"genre_scores_gemma":[0.9761481,0.0007483348,0.02014434,0.00008418741,0.00001282918,0.00003124416,0.0001174101,0.00003930049,0.002674256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269992,"threshold_uncertainty_score":0.004248559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231183161370221,"score_gpt":0.2600533496152836,"score_spread":0.2477415180015814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}