{"id":"W3194418941","doi":"10.1021/acsabm.1c00431","title":"Visible Fluorescent Light-up Probe for DNA Three-Way Junctions Provides Host–Guest Biosensing Applications","year":2021,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Fluorescence; DNA; Biosensor; Chemistry; Biophysics; Combinatorial chemistry; Biochemistry; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002362397,0.0003140678,0.000352369,0.00007677282,0.0003438097,0.000175932,0.0001817284,0.0002890194,0.000005605674],"category_scores_gemma":[0.00005215963,0.0002761502,0.0001193403,0.0002520476,0.0001104958,0.0000077515,0.0001846598,0.00006258106,0.00001661751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000333502,"about_ca_system_score_gemma":0.0001042605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006785252,"about_ca_topic_score_gemma":0.00007115372,"domain_scores_codex":[0.9981717,0.00003403384,0.0004609622,0.0007747968,0.0001520764,0.0004064184],"domain_scores_gemma":[0.9986442,0.00001609323,0.0002208442,0.0007207184,0.0003049966,0.00009310403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008937241,0.0001158503,0.00001364042,0.00007222897,0.00009674617,0.000001180927,0.000008886438,2.220038e-7,0.9933656,0.001050777,0.003514165,0.001671328],"study_design_scores_gemma":[0.0003262617,0.00007732612,0.00005712815,0.00002562986,0.0001060009,0.00001486396,0.00005186117,0.000001062403,0.893902,0.0005731945,0.1045235,0.0003411503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9068496,0.0007907812,0.07969975,0.002670668,0.001990868,0.005216458,0.0008384329,0.0006930227,0.001250424],"genre_scores_gemma":[0.9771535,0.000187762,0.01847426,0.0003851963,0.001182835,0.000470863,0.001399657,0.00006325682,0.0006826248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1010094,"threshold_uncertainty_score":0.9999691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01231183161370221,"score_gpt":0.2600533496152836,"score_spread":0.2477415180015814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}