{"id":"W3194429602","doi":"10.1016/j.jbc.2021.101107","title":"Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Windsor; University of Guelph; Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Natural Sciences and Engineering Research Council of Canada; Takeda Canada; Innovative Medicines Initiative; Ontario Ministry of Research, Innovation and Science; Novartis; Ontario Genomics Institute; Canada Foundation for Innovation; Wellcome Trust; Boehringer Ingelheim; Janssen Pharmaceuticals; Merck KGaA; Meso Scale Diagnostics; AbbVie; Bayer; Genome Canada; Pfizer","keywords":"Deubiquitinating enzyme; Ubiquitin; Proteases; Drug discovery; Cysteine protease; Computational biology; Protease; Small molecule; Biology; Biochemistry; Enzyme; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753947,0.0002835871,0.0002081366,0.0001620182,0.0001823144,0.0002158833,0.0003182,0.0002862855,0.0008960809],"category_scores_gemma":[0.0002095362,0.0001239589,0.0002002436,0.0001723423,0.000140272,0.0001423253,0.00009110961,0.0003801356,0.0002941475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004625628,"about_ca_system_score_gemma":0.0001889761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655452,"about_ca_topic_score_gemma":0.00114865,"domain_scores_codex":[0.9998896,0.00001625985,0.00000927194,0.00001381908,0.00004851269,0.00002244894],"domain_scores_gemma":[0.9999233,0.00001283895,0.00002101397,0.000009067383,0.00001362316,0.00002015103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685456,0.00008205032,0.0003102947,0.0000303656,0.00001792394,0.00007079179,0.00001296912,0.000749593,0.9955188,0.0002911184,0.0001072746,0.002640214],"study_design_scores_gemma":[0.00002134001,0.000239291,0.002195034,0.000002150412,0.00001607749,0.0003084872,0.000009456295,0.002662263,0.9920303,0.00002502811,0.002485004,0.000005632488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944148,0.001435348,0.002438458,0.00005123076,0.00001098997,0.00002951037,0.0005326021,0.00004411796,0.001042916],"genre_scores_gemma":[0.994801,0.000545703,0.001864172,0.00002886869,0.000003119056,0.00001984807,0.001297175,0.00001871148,0.001421386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009655452,"threshold_uncertainty_score":0.003356159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02579317804974681,"score_gpt":0.2376849816410781,"score_spread":0.2118918035913313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}