{"id":"W3194462435","doi":"10.1192/bjp.2021.102","title":"Characterisation of age and polarity at onset in bipolar disorder","year":2021,"lang":"en","type":"article","venue":"The British Journal of Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Nova Scotia Health Authority; Centre for Addiction and Mental Health; Centre for Movement Disorders; Montreal Neurological Institute and Hospital; Dalhousie University; University of Toronto; Douglas Mental Health University Institute; McGill University","funders":"Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; National Institute of Mental Health; Sahlgrenska Akademin; Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; SUNY Downstate Medical Center; Institute for Translational Neuroscience; University of California, Los Angeles; Université de Paris; Broad Institute; Universität Duisburg-Essen; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Diakonhjemmet; Rheinische Friedrich-Wilhelms-Universität Bonn; Hôpitaux Universitaires de Genève; State University of New York; Università degli Studi di Salerno; Universitat de Barcelona; Göteborgs Universitet; Centro de Investigación Biomédica en Red de Salud Mental; Ludwig-Maximilians-Universität München; University of California, San Diego; Johns Hopkins University; Universitetet i Oslo; Universitetet i Bergen; Umeå Universitet; Karolinska Institutet; Universitair Medisch Centrum Utrecht; Campbell Family Mental Health Research Institute; University of Adelaide; University of Melbourne; University of Toronto; School of Medicine, Indiana University; University of New South Wales; Cardiff University; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; University of Cambridge; Vanderbilt University Medical Center; Stony Brook University; Université de Genève; Trinity College Dublin; Neuroscience Research Australia; University College London; Wellcome Trust; Institut National de la Santé et de la Recherche Médicale; Università degli Studi di Cagliari; Vanderbilt University; University of Pennsylvania; Philipps-Universität Marburg; Universität Basel; McGill University; University of Worcester; Dalhousie University; Universitätsmedizin Göttingen; Westfälische Wilhelms-Universität Münster; Emory University; Genomic Health; Department of Psychiatry, University of Toronto; Assistance publique-Hôpitaux de Paris; Massachusetts General Hospital","keywords":"Bipolar disorder; Genome-wide association study; Age of onset; Bipolar I disorder; Schizophrenia (object-oriented programming); Psychology; Genetic association; Genetic architecture; Disease; Heritability; Autism spectrum disorder; Major depressive disorder; Psychiatry; Single-nucleotide polymorphism; Clinical psychology; Medicine; Mania; Genetics; Internal medicine; Autism; Lithium (medication); Cognition; Genotype; Phenotype; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471925,0.0000646847,0.0002270245,0.00004174617,0.00008928843,0.00002699217,0.0000460106,0.00005110976,0.00007448978],"category_scores_gemma":[0.00003471591,0.00005481766,0.00008786773,0.0001196032,0.00005836723,0.00006261972,0.00002938129,0.0002369354,0.000001451328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002611667,"about_ca_system_score_gemma":0.0001192277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003985633,"about_ca_topic_score_gemma":0.006688878,"domain_scores_codex":[0.9992515,0.00009111977,0.0003180508,0.00007763775,0.0001624953,0.00009914874],"domain_scores_gemma":[0.9995896,0.00002305405,0.0001591064,0.0001081441,0.00006475387,0.00005531198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001065739,0.0005022133,0.9740093,0.00006461252,0.00009209074,0.0001441558,0.0002233589,2.334818e-7,0.0007258037,0.0000481457,0.000161028,0.02392245],"study_design_scores_gemma":[0.001876186,0.0001354981,0.9862177,0.0003117105,0.0001172157,0.007605758,0.0002349583,0.000002306772,0.0001329695,0.0008922608,0.002427516,0.00004597047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8748381,0.1218313,0.00001401007,0.002917182,0.0001976365,0.00006626326,0.0000202298,0.000002283066,0.0001130761],"genre_scores_gemma":[0.9935657,0.00547023,0.0005649722,0.0001686797,0.00007950025,7.653205e-7,0.00001461677,0.000009413329,0.0001260752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1187277,"threshold_uncertainty_score":0.3732551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009074919124863978,"score_gpt":0.2487934240592535,"score_spread":0.2397185049343895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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