{"id":"W3194462435","doi":"10.1192/bjp.2021.102","title":"Characterisation of age and polarity at onset in bipolar disorder","year":2021,"lang":"en","type":"article","venue":"The British Journal of Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Nova Scotia Health Authority; Centre for Addiction and Mental Health; Centre for Movement Disorders; Montreal Neurological Institute and Hospital; Dalhousie University; University of Toronto; Douglas Mental Health University Institute; McGill University","funders":"Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles; National Institute of Mental Health; Sahlgrenska Akademin; Medical Research Council; Stanley Center for Psychiatric Research, Broad Institute; SUNY Downstate Medical Center; Institute for Translational Neuroscience; University of California, Los Angeles; Université de Paris; Broad Institute; Universität Duisburg-Essen; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Diakonhjemmet; Rheinische Friedrich-Wilhelms-Universität Bonn; Hôpitaux Universitaires de Genève; State University of New York; Università degli Studi di Salerno; Universitat de Barcelona; Göteborgs Universitet; Centro de Investigación Biomédica en Red de Salud Mental; Ludwig-Maximilians-Universität München; University of California, San Diego; Johns Hopkins University; Universitetet i Oslo; Universitetet i Bergen; Umeå Universitet; Karolinska Institutet; Universitair Medisch Centrum Utrecht; Campbell Family Mental Health Research Institute; University of Adelaide; University of Melbourne; University of Toronto; School of Medicine, Indiana University; University of New South Wales; Cardiff University; International Max Planck Research School for Environmental, Cellular and Molecular Microbiology; University of Cambridge; Vanderbilt University Medical Center; Stony Brook University; Université de Genève; Trinity College Dublin; Neuroscience Research Australia; University College London; Wellcome Trust; Institut National de la Santé et de la Recherche Médicale; Università degli Studi di Cagliari; Vanderbilt University; University of Pennsylvania; Philipps-Universität Marburg; Universität Basel; McGill University; University of Worcester; Dalhousie University; Universitätsmedizin Göttingen; Westfälische Wilhelms-Universität Münster; Emory University; Genomic Health; Department of Psychiatry, University of Toronto; Assistance publique-Hôpitaux de Paris; Massachusetts General Hospital","keywords":"Bipolar disorder; Genome-wide association study; Age of onset; Bipolar I disorder; Schizophrenia (object-oriented programming); Psychology; Genetic association; Genetic architecture; Disease; Heritability; Autism spectrum disorder; Major depressive disorder; Psychiatry; Single-nucleotide polymorphism; Clinical psychology; Medicine; Mania; Genetics; Internal medicine; Autism; Lithium (medication); Cognition; Genotype; Phenotype; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491138,0.0002773067,0.0003022838,0.0009973339,0.0003069941,0.0005975683,0.0001830848,0.0003466463,0.001776767],"category_scores_gemma":[0.001807318,0.0001510405,0.0003947299,0.0008846915,0.0002054017,0.0002992992,0.0003574294,0.0003572897,0.0002369071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199426,"about_ca_system_score_gemma":0.0001790669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00297423,"about_ca_topic_score_gemma":0.00441135,"domain_scores_codex":[0.9997175,0.0000743053,0.0000328297,0.00007411859,0.00005139782,0.00004986619],"domain_scores_gemma":[0.9983962,0.0002507692,0.0009609207,0.00007400821,0.0001230421,0.0001949526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001739256,0.000009065018,0.9965852,0.00001069992,0.00004333365,0.000113187,0.00007897272,0.00002898331,0.001119525,0.00002463249,0.00006967636,0.001742788],"study_design_scores_gemma":[0.000002089147,0.00002898426,0.9994906,0.000004585797,0.000009541057,0.0002499321,0.00004175518,0.00003441468,0.00004268089,0.00003233619,0.00006146464,0.000001543823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983558,0.0004592473,0.0001779208,0.00003862816,0.000008717629,0.000008817774,0.0004531806,0.000004116926,0.0004936032],"genre_scores_gemma":[0.999171,0.0001608306,0.0001034238,0.00002062989,0.000009670668,0.000004954173,0.0004293311,0.000003410908,0.00009671752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00297423,"threshold_uncertainty_score":0.005943835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009074919124863978,"score_gpt":0.2487934240592535,"score_spread":0.2397185049343895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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