{"id":"W3194469015","doi":"10.14814/phy2.14961","title":"Muscle‐specific sirtuin 3 overexpression does not attenuate the pathological effects of high‐fat/high‐sucrose feeding but does enhance cardiac SERCA2a activity","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; St. Boniface Hospital","funders":"Heart and Stroke Foundation of Canada","keywords":"SIRT3; Sirtuin; Acetylation; Endocrinology; Internal medicine; Cardiac muscle; Cardiac function curve; Pathological; Phospholamban; Sirtuin 1; Skeletal muscle; Medicine; Chemistry; Biology; Heart failure; Biochemistry; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006457315,0.0004449799,0.001339664,0.00004860834,0.0002791536,0.00003552757,0.0001776367,0.000388233,0.0002884271],"category_scores_gemma":[0.002169284,0.0001750434,0.0004763008,0.0002861779,0.0005611651,0.0001078748,0.0004038343,0.0008696685,0.00001176605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007885956,"about_ca_system_score_gemma":0.00006787583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001033379,"about_ca_topic_score_gemma":0.000001427479,"domain_scores_codex":[0.9962113,0.000473152,0.0007401508,0.001106296,0.0008710537,0.0005980445],"domain_scores_gemma":[0.9965938,0.00112803,0.0005342364,0.001149385,0.0003279164,0.0002666365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003438109,0.0005195369,0.001631515,0.0002385362,0.00008952955,0.003413855,0.00009174022,0.00001300611,0.9837174,0.0001150273,0.0007647226,0.009061301],"study_design_scores_gemma":[0.0004530401,0.0003964536,0.3632701,0.0004646977,0.0000959497,0.00007734376,0.0001052591,0.00001063873,0.6331238,0.001210215,0.0005973808,0.0001950961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947906,0.0007089977,0.00009841051,0.001452,0.001918525,0.000653002,0.00002556467,0.0001225442,0.0002304118],"genre_scores_gemma":[0.9948013,0.001271026,0.0003559261,0.0006175943,0.001525657,0.000096681,0.00004939332,0.00003158658,0.001250794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3616386,"threshold_uncertainty_score":0.7138065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01523895420130216,"score_gpt":0.2757447744121478,"score_spread":0.2605058202108456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}