{"id":"W3194509158","doi":"10.1371/journal.pgen.1009695","title":"Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Institute of Justice; National Heart, Lung, and Blood Institute; Vlaamse regering; University of Bristol; University of Washington; University of California Research Initiatives; Pennsylvania State University; Indiana University-Purdue University Indianapolis; National Human Genome Research Institute; Wellcome Trust; National Institute of Dental and Craniofacial Research; Fonds Wetenschappelijk Onderzoek; University of Pennsylvania; Science Foundation Ireland; KU Leuven; March of Dimes Foundation; Medical Research Council; Howard Hughes Medical Institute; U.S. Department of Defense","keywords":"Biology; Craniofacial; Evolutionary biology; Genetics; Population; Genome-wide association study; Genetic architecture; Population stratification; Phenotype; Single-nucleotide polymorphism; Gene; Genotype; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000657584,0.0001021247,0.000155892,0.00003682863,0.00006657036,0.00001609868,0.00009861546,0.0001855293,0.000005203574],"category_scores_gemma":[0.00005298152,0.0001148283,0.00004770266,0.0001355562,0.00007939545,0.000001626253,0.0001053126,0.00008889083,5.143305e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001570543,"about_ca_system_score_gemma":0.00005585355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002121667,"about_ca_topic_score_gemma":0.0003575203,"domain_scores_codex":[0.9992258,0.00003628228,0.000234917,0.0002639485,0.00008465911,0.0001544213],"domain_scores_gemma":[0.9994905,0.000007768772,0.0001005148,0.0002402518,0.0001152713,0.00004570011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000005707036,0.000141204,0.1435647,0.000009264373,0.00002915582,6.876439e-7,0.00004703869,0.0003331331,0.8554468,0.0002418168,0.00006524641,0.0001152911],"study_design_scores_gemma":[0.0003669469,0.00007508753,0.7338294,0.000008897921,0.00003248678,0.00001031073,0.00005162963,0.0003091467,0.2630325,0.0001321261,0.001972515,0.0001788871],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949346,0.0007417444,0.003074281,0.0001715047,0.00001852185,0.0001721097,0.0003785808,0.000009067251,0.0004995928],"genre_scores_gemma":[0.992017,0.0001257408,0.0067125,0.00007059634,0.00005551035,0.00002984894,0.0008324634,0.00001337481,0.00014291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5924143,"threshold_uncertainty_score":0.4682562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02095099005306532,"score_gpt":0.2886512391781349,"score_spread":0.2677002491250696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}