{"id":"W3194520351","doi":"10.1016/j.celrep.2021.109587","title":"Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Institute of General Medical Sciences; Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley; National Institutes of Health; National Science Foundation","keywords":"CD47; Phagocytosis; Antibody; Macrophage; Receptor; Fc receptor; Blocking antibody; Cell biology; Phosphorylation; Immune system; Biology; Effector; Cancer immunotherapy; Immunotherapy; Chemistry; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002777822,0.0003079406,0.0002211048,0.0001720445,0.0001075271,0.0005368778,0.0002371923,0.0002940042,0.0009564229],"category_scores_gemma":[0.0002597849,0.0001774567,0.0001485049,0.0001382155,0.0003278067,0.0002846213,0.0002329899,0.0004967963,0.000322757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003904546,"about_ca_system_score_gemma":0.0001904429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002324808,"about_ca_topic_score_gemma":0.000338501,"domain_scores_codex":[0.9997101,0.00006708484,0.00002059843,0.00005222276,0.00006837145,0.00008152822],"domain_scores_gemma":[0.9998247,0.00004209175,0.00006718819,0.00001325894,0.00001871999,0.0000339917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008924957,0.00002017528,0.0001365173,0.00001298793,0.000002199482,0.00001041813,0.000005501316,0.00003691389,0.9990582,0.00008250789,0.00001683372,0.0005285381],"study_design_scores_gemma":[0.000009355432,0.000101114,0.00128558,0.000002100455,0.000006261306,0.00006165123,0.00001009018,0.0009735168,0.9971167,0.00002914224,0.0004020994,0.000002317781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946649,0.001088205,0.002929664,0.0001006738,0.00001378662,0.00001393503,0.00005652218,0.00005271613,0.001079603],"genre_scores_gemma":[0.9973693,0.000483867,0.001499423,0.00004652937,0.000005954151,0.00001473338,0.00004887288,0.00001511831,0.000516265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009564229,"threshold_uncertainty_score":0.003199518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081742265956287,"score_gpt":0.2464265151272474,"score_spread":0.2356090924676846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}