{"id":"W3194520351","doi":"10.1016/j.celrep.2021.109587","title":"Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"National Institute of General Medical Sciences; Adolph C. and Mary Sprague Miller Institute for Basic Research in Science, University of California Berkeley; National Institutes of Health; National Science Foundation","keywords":"CD47; Phagocytosis; Antibody; Macrophage; Receptor; Fc receptor; Blocking antibody; Cell biology; Phosphorylation; Immune system; Biology; Effector; Cancer immunotherapy; Immunotherapy; Chemistry; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002546026,0.0002760814,0.0004288034,0.00005543929,0.0003426014,0.00005624174,0.00009645298,0.0003240612,0.003601042],"category_scores_gemma":[0.000106209,0.0002731658,0.000205783,0.0002954259,0.0001656332,0.0003418844,0.0001066127,0.0002502563,0.0004680715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060128,"about_ca_system_score_gemma":0.0001690634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005684452,"about_ca_topic_score_gemma":0.00000638257,"domain_scores_codex":[0.9979684,0.0002249309,0.0006953104,0.0006240565,0.00009147063,0.0003958287],"domain_scores_gemma":[0.9984797,0.00009676701,0.0004744542,0.0006174732,0.0003010795,0.00003052056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004218048,0.0002085059,0.001800236,0.0000281741,0.0001016564,0.0001184109,0.0005723758,0.00002778913,0.9917084,0.0006528149,0.003409005,0.001330428],"study_design_scores_gemma":[0.0005339303,0.00005548343,0.006668747,0.00005112158,0.00005793682,0.000321173,0.0002987977,0.000009406528,0.8469915,0.0002910642,0.144461,0.0002598048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9246141,0.02362522,0.002186714,0.0002320748,0.003187085,0.0004383865,0.00003552664,0.0001974877,0.0454834],"genre_scores_gemma":[0.9743878,0.0006557971,0.0005069672,0.0001724505,0.00007651786,0.00002185977,0.00331859,0.00003734116,0.02082262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1447169,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081742265956287,"score_gpt":0.2464265151272474,"score_spread":0.2356090924676846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}