{"id":"W3194564548","doi":"10.11575/prism/39109","title":"A Prion Protein Gene Polymorphism at Codon 138 Modulates Chronic Wasting Disease Pathogenesis","year":2021,"lang":"en","type":"dissertation","venue":"PRISM (University of Calgary)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chronic wasting disease; Pathogenesis; Gene; Disease; Genetics; Prion protein; Polymorphism (computer science); Biology; Medicine; Genotype; Immunology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009552343,0.0002352811,0.000166982,0.0001698988,0.0001276884,0.0001876646,0.0001202041,0.0001825428,0.0008269185],"category_scores_gemma":[0.0002160176,0.00008294126,0.0000911841,0.0001746131,0.0002310612,0.00007486578,0.0001061936,0.0002180544,0.00009039772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001713291,"about_ca_system_score_gemma":0.0002170433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006798997,"about_ca_topic_score_gemma":0.009206886,"domain_scores_codex":[0.9999242,0.00001416106,0.00000584157,0.00001996081,0.00001642826,0.00001934227],"domain_scores_gemma":[0.9998401,0.00002214594,0.00005148836,0.000007405444,0.00002187047,0.00005700063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001177448,0.0002041732,0.1135889,0.00003244896,0.00005560267,0.0006572331,0.0002476601,0.00005190509,0.8815708,0.00005406414,0.00006669642,0.002293117],"study_design_scores_gemma":[0.00004587662,0.0009678844,0.9800537,0.000008629296,0.00007625461,0.001039788,0.0001849986,0.0004412014,0.01665709,0.00005701977,0.0004609713,0.000006567264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998068,0.00003426935,0.00003850145,0.000006128443,0.000001808157,0.000001945208,0.0000169841,0.000001452793,0.00009207383],"genre_scores_gemma":[0.9996045,0.0000404635,0.00006976353,0.00001108736,0.000002017858,0.000002830339,0.00004035278,0.000001804565,0.0002271556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006798997,"threshold_uncertainty_score":0.01351881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006093421227460194,"score_gpt":0.1944847615530685,"score_spread":0.1883913403256083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}