{"id":"W3194583703","doi":"10.33774/chemrxiv-2021-d3dr8","title":"ZIF-C as non-viral delivery system for CRISPR/Cas9 mediated hTERT knockdown in cancer cells","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RMIT University; Australian Government; David and Elaine Potter Foundation; Ontario Ministry of Natural Resources and Forestry","keywords":"CRISPR; Telomerase reverse transcriptase; Telomerase; Cas9; Cancer cell; Cancer research; Gene knockdown; Carcinogenesis; Biology; Ribonucleoprotein; Cancer; Chemistry; Gene; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023099,0.0003173357,0.0003678058,0.0002950705,0.0002287523,0.0003857044,0.0004412262,0.0006825933,0.001782276],"category_scores_gemma":[0.000143745,0.0001943236,0.0003195867,0.0002275041,0.0001900837,0.0002265168,0.0002500639,0.0007849333,0.0009482277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004833072,"about_ca_system_score_gemma":0.0003127625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002616514,"about_ca_topic_score_gemma":0.002359947,"domain_scores_codex":[0.9997036,0.00002052603,0.00002272085,0.00008018041,0.0001238639,0.0000490946],"domain_scores_gemma":[0.9999427,0.000009598976,0.00001407111,0.00001118962,0.00001299725,0.000009499838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002281091,0.000009591236,0.00003842217,0.00003802568,0.000004155151,0.00004442342,0.0000130396,0.0001085597,0.9977463,0.0002588714,0.0001496699,0.001566071],"study_design_scores_gemma":[0.000005098075,0.00002261139,0.0002876948,0.000002377767,0.000006108205,0.00009971305,0.000003262743,0.001103758,0.9947875,0.00001919483,0.003658766,0.000003904057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.77537,0.004736274,0.197634,0.0005720538,0.0004177136,0.0007419677,0.004835642,0.002744233,0.01294805],"genre_scores_gemma":[0.8884763,0.002031638,0.08381758,0.0001864054,0.00002861821,0.0003495434,0.003969394,0.0003207868,0.02081972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616514,"threshold_uncertainty_score":0.005962253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01048167934074425,"score_gpt":0.2945063611748589,"score_spread":0.2840246818341147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}