{"id":"W3194598620","doi":"10.3390/curroncol28050280","title":"Multitumor Case Series of Germline BRCA1, BRCA2 and CHEK2-Mutated Patients Responding Favorably on Immune Checkpoint Inhibitors","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fonds Wetenschappelijk Onderzoek; Ipsen; Kom op tegen Kanker; Pfizer","keywords":"Germline; CHEK2; Medicine; Germline mutation; Immune checkpoint; Somatic cell; Cancer research; DNA damage; Disease; Immune system; Mutation; Gene; Immunotherapy; Bioinformatics; Immunology; Genetics; Biology; DNA; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000269791,0.0008309092,0.0005516136,0.001328356,0.001654124,0.0008348926,0.000509009,0.001091681,0.002623159],"category_scores_gemma":[0.001309398,0.0005073766,0.0005893784,0.0006901047,0.001085458,0.0005587451,0.001005183,0.0008172991,0.0005506746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004108605,"about_ca_system_score_gemma":0.0003413836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007085614,"about_ca_topic_score_gemma":0.001153027,"domain_scores_codex":[0.9995987,0.00003962202,0.00006299189,0.0001301955,0.00005527461,0.0001131506],"domain_scores_gemma":[0.9986439,0.0003601399,0.0002962037,0.0001727883,0.00008077273,0.0004462796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002722555,0.0002052106,0.1776047,0.00006593065,0.00009730527,0.8095592,0.0006093533,0.0003531782,0.004249102,0.0002300073,0.0006562262,0.006097428],"study_design_scores_gemma":[0.00002432937,0.0001919119,0.03686776,0.00001039516,0.00005282986,0.959789,0.0002259458,0.000328082,0.00150551,0.0001342288,0.00085573,0.00001429551],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951499,0.0007129634,0.0007549535,0.0002496567,0.00004698997,0.00005227992,0.0000923707,0.00003824187,0.002902659],"genre_scores_gemma":[0.9989116,0.0001919389,0.0002399845,0.0000887131,0.0000771394,0.00001102444,0.00007592377,0.000009657007,0.0003939432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002623159,"threshold_uncertainty_score":0.008775353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05014658346155843,"score_gpt":0.3598919716392711,"score_spread":0.3097453881777126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}