{"id":"W3194625583","doi":"10.1016/j.cell.2021.08.016","title":"The interferon landscape along the respiratory tract impacts the severity of COVID-19","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Wellcome Trust; Francis Crick Institute; Fondazione IRCCS Policlinico San Matteo; National Institutes of Health; Cancer Research UK; Burroughs Wellcome Fund","keywords":"Biology; Respiratory tract; Interferon; Coronavirus disease 2019 (COVID-19); Immunology; Coronavirus; Immune system; Disease; Respiratory system; Lung; Interferon type I; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Gene; Respiratory disease; Virology; Infectious disease (medical specialty); Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002340738,0.0001157132,0.0002413652,0.00002007938,0.0003335445,0.00003368325,0.000331241,0.00006264369,0.0002201662],"category_scores_gemma":[0.03417562,0.00004667001,0.0001837254,0.0002493648,0.0004541814,0.00002992469,0.0003339193,0.000574732,0.00003913563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009490453,"about_ca_system_score_gemma":0.001165472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001651138,"about_ca_topic_score_gemma":0.0003172162,"domain_scores_codex":[0.998251,0.0004271434,0.0003321737,0.0002167872,0.0004647962,0.0003080985],"domain_scores_gemma":[0.9839615,0.01463077,0.0001142717,0.000883935,0.0001964411,0.0002130783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004168258,0.002380149,0.4432902,0.004455503,0.0009974196,0.0009557733,0.01642784,0.0002005366,0.04445817,0.0005757256,0.4492151,0.03287535],"study_design_scores_gemma":[0.001967384,0.0006376454,0.3137449,0.00009553503,0.0001426743,0.000008567581,0.002668921,0.000182738,0.01308551,0.0004290453,0.666907,0.0001301519],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8810155,0.007826586,0.0001121425,0.1047987,0.0002704702,0.0006562534,0.00002248406,0.00004155274,0.005256239],"genre_scores_gemma":[0.9873331,0.001037817,0.000005492868,0.009855134,0.0001807598,0.00001860415,0.000002615285,0.00001198848,0.001554536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2176918,"threshold_uncertainty_score":0.9739599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07340820606646199,"score_gpt":0.4182699072881501,"score_spread":0.3448617012216881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}