{"id":"W3194625583","doi":"10.1016/j.cell.2021.08.016","title":"The interferon landscape along the respiratory tract impacts the severity of COVID-19","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Wellcome Trust; Francis Crick Institute; Fondazione IRCCS Policlinico San Matteo; National Institutes of Health; Cancer Research UK; Burroughs Wellcome Fund","keywords":"Biology; Respiratory tract; Interferon; Coronavirus disease 2019 (COVID-19); Immunology; Coronavirus; Immune system; Disease; Respiratory system; Lung; Interferon type I; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Gene; Respiratory disease; Virology; Infectious disease (medical specialty); Genetics; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003074897,0.0002081108,0.0002921353,0.0003144587,0.0002480881,0.0005309739,0.00009675186,0.0002610193,0.002117413],"category_scores_gemma":[0.0003949058,0.00009759472,0.000160435,0.0002380417,0.0002724134,0.0002172431,0.000273912,0.0004165582,0.0003347688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002054076,"about_ca_system_score_gemma":0.000170571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003267372,"about_ca_topic_score_gemma":0.0004770115,"domain_scores_codex":[0.9997738,0.00006559883,0.0000183092,0.00005500551,0.00003582019,0.00005134074],"domain_scores_gemma":[0.9997891,0.00003531715,0.00007573862,0.00001233242,0.00003145975,0.00005613192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0038506,0.0002524951,0.4151549,0.0001494733,0.00006537216,0.001167185,0.0003421236,0.0001320426,0.5593712,0.0002452069,0.0003074733,0.01896192],"study_design_scores_gemma":[0.00003598892,0.001359354,0.9667183,0.00003156891,0.00004921595,0.002046149,0.0006750399,0.0002686273,0.02657982,0.0001654159,0.002061786,0.000008747318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976736,0.001031908,0.0001691531,0.00006504627,0.000007149452,0.0000147586,0.0001106753,0.000004052563,0.0009236818],"genre_scores_gemma":[0.9988108,0.0003837485,0.0001408467,0.00006275794,0.00001107733,0.00000948163,0.0001674774,0.000001923153,0.0004120289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002117413,"threshold_uncertainty_score":0.007083476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07340820606646199,"score_gpt":0.4182699072881501,"score_spread":0.3448617012216881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}