{"id":"W3194699696","doi":"10.1080/16078454.2021.1959984","title":"Refractory acquired thrombotic thrombocytopenic purpura in a patient with sickle cell trait successfully treated with caplacizumab","year":2021,"lang":"en","type":"article","venue":"Hematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Health Authority; Saskatchewan Health; University of Saskatchewan","funders":"","keywords":"Sickle cell trait; Medicine; Thrombotic thrombocytopenic purpura; ADAMTS13; Refractory (planetary science); Autoantibody; Immunology; Internal medicine; Pediatrics; Platelet; Disease; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007741663,0.0003753886,0.0009387361,0.0001638261,0.0001363626,0.00002286993,0.0002748462,0.0002382323,0.003572047],"category_scores_gemma":[0.00002956801,0.0002898652,0.00008107565,0.0003992827,0.000305523,0.0001444692,0.0001204419,0.0002114619,0.0003270593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001372644,"about_ca_system_score_gemma":0.0003979745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002730848,"about_ca_topic_score_gemma":0.00218574,"domain_scores_codex":[0.9974083,0.0005285753,0.0005659219,0.0007102401,0.0000860326,0.000700977],"domain_scores_gemma":[0.9986208,0.000244172,0.0002614727,0.0006732456,0.0001468145,0.00005347527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009670141,0.01578219,0.4545984,0.002283938,0.003167453,0.02796287,0.01022545,0.0002609436,0.4410974,0.01082076,0.02103892,0.003091596],"study_design_scores_gemma":[0.04376491,0.006210275,0.1496079,0.00153076,0.0009544619,0.02857372,0.01646498,0.00002681708,0.7322275,0.000373676,0.0173432,0.002921808],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923596,0.003302926,0.00003307292,0.0002119184,0.0001490137,0.0006591076,0.00005807061,0.0001233987,0.003102833],"genre_scores_gemma":[0.9985193,0.00001835026,0.000113604,0.0001495669,0.000007703864,0.0001908283,0.0003561108,0.00004611781,0.0005984444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3049905,"threshold_uncertainty_score":0.9999554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099575742150062,"score_gpt":0.2245760727018849,"score_spread":0.2135803152803843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}