{"id":"W3194711549","doi":"10.1016/j.jaad.2021.06.336","title":"25983 Rates of individual and composite cardiovascular events through 5 years of tildrakizumab exposure in 2 phase 3 clinical trials","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Monoclonal; Clinical trial; Plaque psoriasis; Psoriasis; Internal medicine; Dermatology; Monoclonal antibody; Interleukin 23; Immunology; Antibody; Interleukin; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006331336,0.0007447305,0.001886729,0.0003996554,0.0003870012,0.001194783,0.0004782059,0.001166668,0.003839032],"category_scores_gemma":[0.004251594,0.0006198951,0.003272491,0.0007921793,0.0004703919,0.0008593341,0.0004210743,0.001761426,0.0006448569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005609174,"about_ca_system_score_gemma":0.000834603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006319715,"about_ca_topic_score_gemma":0.001592685,"domain_scores_codex":[0.996626,0.002030358,0.0003028965,0.000491038,0.0003008387,0.0002489355],"domain_scores_gemma":[0.9968649,0.0012586,0.001066799,0.0003127259,0.0002398784,0.0002570662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8452283,0.004141042,0.04352396,0.00157386,0.01413728,0.0001930796,0.0001794297,0.001857173,0.008420964,0.0003861189,0.0053501,0.07500871],"study_design_scores_gemma":[0.5010738,0.2011281,0.2567285,0.0003790832,0.01943629,0.0006134587,0.0001645708,0.002350323,0.004042933,0.0007659839,0.01318594,0.0001310855],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756158,0.01334107,0.001268937,0.0004407088,0.0002120431,0.00105365,0.003618712,0.00009696586,0.004352148],"genre_scores_gemma":[0.9900154,0.002796229,0.0008318399,0.000514727,0.0001580915,0.000850751,0.002527516,0.0000349423,0.002270283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006331336,"threshold_uncertainty_score":0.03348374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07598746161508962,"score_gpt":0.3896118196089398,"score_spread":0.3136243579938501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}