{"id":"W3194729933","doi":"10.1038/s41598-021-96127-8","title":"RT-QuIC detection of CWD prion seeding activity in white-tailed deer muscle tissues","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Minnesota Agricultural Experiment Station; Animal and Plant Health Inspection Service; National Institutes of Health; University of Minnesota; Legislative-Citizen Commission on Minnesota Resources; U.S. Department of Agriculture; Minnesota Environment and Natural Resources Trust Fund; Minnesota Department of Natural Resources","keywords":"Chronic wasting disease; Biology; Odocoileus; Livestock; Prion protein; Disease; Zoology; Ecology; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007486955,0.0008310272,0.0003268842,0.0008348587,0.0003193311,0.0004562381,0.0003148228,0.000546634,0.001148232],"category_scores_gemma":[0.0009293531,0.0002768401,0.0004187669,0.000400826,0.0004893375,0.000291546,0.0001990132,0.000742866,0.0007843826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527863,"about_ca_system_score_gemma":0.00025405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007659234,"about_ca_topic_score_gemma":0.001892103,"domain_scores_codex":[0.9994206,0.00009513137,0.00008458585,0.0001850073,0.0001442196,0.00007032794],"domain_scores_gemma":[0.9991183,0.0003492278,0.0001380392,0.00008212003,0.0002625268,0.00004985032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002218139,0.00001978219,0.0005935424,0.00006111302,0.000005986996,0.00008969192,0.00004352686,0.00002001633,0.9981117,0.00002566684,0.00004241909,0.0009644376],"study_design_scores_gemma":[0.00001017643,0.0003841669,0.01274578,0.00004158161,0.00006344382,0.001099085,0.0001051156,0.001443226,0.9801926,0.00007688557,0.003821936,0.00001599932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9157626,0.003164083,0.07394302,0.0002242513,0.0001824792,0.0004357288,0.002389467,0.0005131525,0.003385205],"genre_scores_gemma":[0.7464633,0.004794827,0.2284088,0.0008800616,0.00008414108,0.0006659108,0.009617442,0.0003118844,0.008773612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148232,"threshold_uncertainty_score":0.003959537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002152246009757,"score_gpt":0.2542027621639437,"score_spread":0.2441812397038461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}