{"id":"W3194774701","doi":"10.1200/po.20.00489","title":"Ethical and Analytic Challenges With Genomic Sequencing of Relapsed Hematologic Malignancies Following Allogeneic Hematopoietic Stem-Cell Transplantation","year":2021,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Canadian Blood Services; Dalhousie University; SickKids Foundation; University of Toronto; University of Ottawa; Hospital for Sick Children","funders":"","keywords":"Transplantation; Hematopoietic stem cell transplantation; Germline; Oncology; Leukemia; DNA sequencing; Stem cell; Cancer; Haematopoiesis; Biology; Medicine; Immunology; Bioinformatics; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1342198,0.0003379841,0.0006787569,0.001283176,0.002158948,0.005490816,0.002195803,0.003898852,0.002205825],"category_scores_gemma":[0.1246176,0.0004834102,0.0005352765,0.0008988039,0.007437544,0.001827555,0.00384565,0.00591374,0.001215352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002137418,"about_ca_system_score_gemma":0.007857202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001766948,"about_ca_topic_score_gemma":0.003222887,"domain_scores_codex":[0.9077584,0.06501406,0.006669355,0.003554754,0.01521108,0.001792271],"domain_scores_gemma":[0.8212798,0.1229718,0.01675472,0.01675414,0.01784163,0.004397874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001765716,0.0003402126,0.09371687,0.001975337,0.000301537,0.0166357,0.02278637,0.008033396,0.02028722,0.1589258,0.1195362,0.5556956],"study_design_scores_gemma":[0.0001559145,0.0007123703,0.03362836,0.005549398,0.0002511697,0.03304277,0.02148518,0.01147186,0.02871292,0.37992,0.4848181,0.0002520018],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1649488,0.02267868,0.2996231,0.4532936,0.006879221,0.002062677,0.001082039,0.0006824398,0.04874947],"genre_scores_gemma":[0.6868218,0.01155734,0.1923379,0.09438941,0.004471434,0.002223051,0.0008021963,0.0003973792,0.00699954],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1342198,"threshold_uncertainty_score":0.7098305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02303035092479876,"score_gpt":0.2738923576790774,"score_spread":0.2508620067542786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}