{"id":"W3194788476","doi":"10.1016/j.bbi.2021.08.219","title":"Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci","year":2021,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute of Mental Health; National Cancer Institute; National Institutes of Health; National Institute on Drug Abuse; Norwegian Sequencing Centre; Haukeland Universitetssjukehus; Norges Forskningsråd; NIH Office of the Director; Universitetet i Oslo","keywords":"Chronic fatigue syndrome; Human leukocyte antigen; Major histocompatibility complex; Encephalomyelitis; Immunology; Histocompatibility; MHC class I; Medicine; Genetics; Biology; Antigen; Multiple sclerosis; Physical therapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397559,0.0002234308,0.0001833423,0.0003991104,0.0002781055,0.000146749,0.0001391898,0.0002368316,0.002111968],"category_scores_gemma":[0.0007030751,0.00009006526,0.0001882131,0.0003663438,0.0003614014,0.00008191027,0.0002197004,0.0002176191,0.0001672518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760298,"about_ca_system_score_gemma":0.0001497463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00689092,"about_ca_topic_score_gemma":0.01028706,"domain_scores_codex":[0.999849,0.00002880281,0.00001287699,0.00006171238,0.00002075647,0.00002687373],"domain_scores_gemma":[0.9997112,0.00009426042,0.00009372742,0.00001708181,0.00002897579,0.00005476878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001048511,0.00007923544,0.8710865,0.0001361954,0.0002060027,0.001228649,0.0004459569,0.0003790816,0.1083395,0.0002599688,0.0003662345,0.016424],"study_design_scores_gemma":[0.00002284058,0.0001037884,0.9981107,0.000009423969,0.00003118866,0.0004937339,0.00007307432,0.0001390736,0.0006230955,0.00005760874,0.0003327949,0.000002782377],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991177,0.0003590142,0.0002061651,0.00002178986,0.000005310705,0.000004631832,0.0001045625,0.000001790333,0.0001790229],"genre_scores_gemma":[0.9994454,0.00009274686,0.0002103964,0.00001286592,0.000005833068,0.000003247433,0.00009638189,8.968833e-7,0.0001322723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00689092,"threshold_uncertainty_score":0.01370162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05096558938380679,"score_gpt":0.309729361445119,"score_spread":0.2587637720613122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}