{"id":"W3194796500","doi":"10.1093/brain/awab134","title":"Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Helse Sør-Øst RHF; Norges Forskningsråd; National Natural Science Foundation of China","keywords":"Hyperphosphorylation; Cell biology; Phosphorylation; Transcription factor; Tau protein; Alzheimer's disease; Biology; E2F1; Senile plaques; Chemistry; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435946,0.0001218915,0.0001587047,0.00001747339,0.0001819087,0.00003950945,0.00006328458,0.00005745111,0.0004858516],"category_scores_gemma":[0.000209298,0.00008060099,0.0001183254,0.0002113255,0.00006440302,0.00009542698,0.00004740405,0.0001438285,0.0001547079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006181511,"about_ca_system_score_gemma":0.0002494842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008518287,"about_ca_topic_score_gemma":0.00002083803,"domain_scores_codex":[0.9988589,0.00009908505,0.0001510723,0.0002490238,0.0003617707,0.0002801077],"domain_scores_gemma":[0.999223,0.0002066453,0.00003917643,0.0002819283,0.0001149615,0.000134306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003479273,0.01158292,0.1792264,0.0008952336,0.04705993,0.01202811,0.01481931,0.002335589,0.3535242,0.02702433,0.1192359,0.2287888],"study_design_scores_gemma":[0.006135241,0.0006010348,0.09399687,0.0003525316,0.000625434,0.000153605,0.001813792,0.005991181,0.8449062,0.02019506,0.02465144,0.0005776058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671779,0.01326516,0.000935402,0.01320946,0.00008023983,0.0005094615,0.00004201073,0.00009376965,0.004686577],"genre_scores_gemma":[0.9970507,0.0001095767,0.0004274534,0.001292908,0.0001500815,0.00003151848,0.0001450526,0.00001948854,0.0007731913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.491382,"threshold_uncertainty_score":0.5319735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0339833859966936,"score_gpt":0.3028224101936983,"score_spread":0.2688390241970047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}