{"id":"W3194796500","doi":"10.1093/brain/awab134","title":"Amyloid-β toxicity modulates tau phosphorylation through the PAX6 signalling pathway","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Helse Sør-Øst RHF; Norges Forskningsråd; National Natural Science Foundation of China","keywords":"Hyperphosphorylation; Cell biology; Phosphorylation; Transcription factor; Tau protein; Alzheimer's disease; Biology; E2F1; Senile plaques; Chemistry; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009828695,0.0003196366,0.0001525574,0.0002139377,0.0001908601,0.0002895708,0.0001224458,0.0001885157,0.001416969],"category_scores_gemma":[0.00006756228,0.00008543021,0.0002073142,0.0001030005,0.0001646925,0.0002982705,0.000223093,0.0003634293,0.0002139002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650576,"about_ca_system_score_gemma":0.0001200398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002666283,"about_ca_topic_score_gemma":0.0003997112,"domain_scores_codex":[0.9999163,0.00001897488,0.000005916777,0.00001337276,0.00001709554,0.00002831469],"domain_scores_gemma":[0.9999669,0.00000435349,0.00001115082,0.000002432074,0.000004480483,0.00001065984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003271687,0.00003565467,0.0006546341,0.0000846945,0.00001230702,0.0001523773,0.00002832653,0.00009754472,0.9952556,0.0004048796,0.00008230453,0.002864357],"study_design_scores_gemma":[0.00009143088,0.0005469909,0.03282851,0.00003482326,0.00006191232,0.0008221485,0.0001537339,0.002680383,0.9549618,0.000917036,0.006885515,0.00001571746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856221,0.007954096,0.00188733,0.0002182381,0.00004413501,0.0000265523,0.0002952407,0.00006457581,0.003887665],"genre_scores_gemma":[0.9952269,0.002565587,0.0004564001,0.00004303321,0.00001045703,0.00002182752,0.0001927366,0.000005996143,0.001477176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416969,"threshold_uncertainty_score":0.004740298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0339833859966936,"score_gpt":0.3028224101936983,"score_spread":0.2688390241970047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}