{"id":"W3194923171","doi":"10.1016/j.jaad.2021.06.650","title":"27697 Long-term efficacy, safety, and adherence to tralokinumab treatment in moderate-to-severe atopic dermatitis for up to 3 years: Interim readout of ECZTEND, a phase 3, long-term extension trial","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Thomas Hospital; Probity Medical Research","funders":"","keywords":"Medicine; Discontinuation; Atopic dermatitis; Eczema Area and Severity Index; Adverse effect; Interim; Interim analysis; Dermatology Life Quality Index; Clinical endpoint; Dupilumab; Quality of life (healthcare); Randomized controlled trial; Clinical trial; Internal medicine; Physical therapy; Pediatrics; Dermatology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002160317,0.001026619,0.001855141,0.0002792208,0.0005697018,0.001191358,0.0007442659,0.00147737,0.004911582],"category_scores_gemma":[0.001551891,0.0003741026,0.00206163,0.0003346516,0.0007773582,0.001132639,0.0003203942,0.003710774,0.001279811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005162263,"about_ca_system_score_gemma":0.0007071384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006289684,"about_ca_topic_score_gemma":0.001569664,"domain_scores_codex":[0.9993543,0.0002617967,0.00004908269,0.0000925955,0.00009835678,0.0001437976],"domain_scores_gemma":[0.9987929,0.0003565065,0.0002576059,0.0001290057,0.0001047958,0.0003591868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8714766,0.0202585,0.00891977,0.0008313216,0.003140674,0.0001452564,0.0001805968,0.001142147,0.007647149,0.0002342276,0.003431345,0.08259249],"study_design_scores_gemma":[0.6836582,0.251758,0.05452599,0.0001197016,0.002280289,0.0002909832,0.0001507636,0.001833783,0.002289043,0.0003053847,0.002709585,0.00007817082],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945365,0.002191881,0.0001833612,0.0003020765,0.0001448175,0.0003892375,0.0008248059,0.00006093433,0.001366331],"genre_scores_gemma":[0.9930369,0.001250963,0.0004479503,0.000685415,0.0002123989,0.0006011048,0.00136463,0.00001921828,0.002381288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004911582,"threshold_uncertainty_score":0.01643085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04315083769563634,"score_gpt":0.3807826858953954,"score_spread":0.3376318481997591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}