{"id":"W3194923225","doi":"10.1093/hmg/ddab240","title":"Epigenome-wide association study of mitochondrial genome copy number","year":2021,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Mitochondrial DNA; DNA methylation; Biology; CpG site; Methylation; Epigenome; Genetics; DNA binding site; Nuclear DNA; TFAM; Epigenetics; Gene; Molecular biology; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001011611,0.000336137,0.0005067142,0.000893819,0.0003370834,0.0004030913,0.0003615858,0.0004248234,0.001310347],"category_scores_gemma":[0.002140711,0.0002119351,0.0008557274,0.00158601,0.0001778921,0.0002499888,0.0004720112,0.000428835,0.00014995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020264,"about_ca_system_score_gemma":0.0002407041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004521035,"about_ca_topic_score_gemma":0.006329887,"domain_scores_codex":[0.9991431,0.0002257968,0.00005592777,0.0004133417,0.00008440163,0.00007728255],"domain_scores_gemma":[0.9988812,0.0003186658,0.0003274576,0.0001910685,0.0001388536,0.0001427611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009978907,0.00003647898,0.9822106,0.00009194083,0.003339167,0.0002139381,0.0001298755,0.0003063268,0.006377185,0.0001116063,0.000321829,0.005863218],"study_design_scores_gemma":[0.00003577163,0.0001049876,0.9974915,0.000007692237,0.0007143714,0.0001618918,0.00003162736,0.0004058804,0.0003577513,0.00007779272,0.000604635,0.000006089595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9939631,0.001944719,0.001181391,0.00008175102,0.00001770744,0.00001708018,0.002366361,0.00002859317,0.0003994626],"genre_scores_gemma":[0.997241,0.0003602649,0.0007045298,0.00004010142,0.00001584593,0.0000313188,0.001253208,0.000009940159,0.0003438298],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004521035,"threshold_uncertainty_score":0.008989453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03018792011458122,"score_gpt":0.3425555945090694,"score_spread":0.3123676743944882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}