{"id":"W3194946931","doi":"10.3390/biom11081253","title":"Transcriptional Regulation of MECP2E1-E2 Isoforms and BDNF by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ontario Rett Syndrome Association","keywords":"Simvastatin; MECP2; Metformin; Transcription (linguistics); RNA; Gene isoform; Transcriptional regulation; Biology; Pharmacology; Gene expression; Endocrinology; Chemistry; Internal medicine; Gene; Biochemistry; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009174761,0.0001249406,0.0001385584,0.00003911082,0.00005216172,0.00001784905,0.00005125625,0.00007492922,0.00001646974],"category_scores_gemma":[0.00003180096,0.0001241258,0.00004030144,0.00009452528,0.00009191075,0.000005860586,0.00005403709,0.00003466746,2.59215e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006570694,"about_ca_system_score_gemma":0.00002736447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004038393,"about_ca_topic_score_gemma":0.00009553209,"domain_scores_codex":[0.9991942,0.00004262285,0.0002360363,0.0002881911,0.00009754342,0.0001414001],"domain_scores_gemma":[0.9997434,0.00001399921,0.00006538314,0.0001036165,0.00003495916,0.00003864597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002191717,0.00009002098,0.000489899,0.00005413866,0.00001965692,0.000002365662,0.0001269975,0.00001017645,0.9955774,0.0001414313,0.000174195,0.003291797],"study_design_scores_gemma":[0.0004829001,0.0000862786,0.01678095,0.00002588285,0.00001379897,0.000006673667,0.0002385204,0.00006217015,0.9804016,0.0002634132,0.001490809,0.0001470012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929471,0.004128016,0.002289775,0.0002729405,0.00001481933,0.00008902096,0.00005837864,0.000003126958,0.0001968371],"genre_scores_gemma":[0.9958304,0.001007298,0.002689401,0.0001214721,0.000005109384,0.000007852458,0.0002070073,0.00001489752,0.0001166114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01629105,"threshold_uncertainty_score":0.5061701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009420148517637115,"score_gpt":0.239378234390436,"score_spread":0.2299580858727989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}