{"id":"W3194946931","doi":"10.3390/biom11081253","title":"Transcriptional Regulation of MECP2E1-E2 Isoforms and BDNF by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ontario Rett Syndrome Association","keywords":"Simvastatin; MECP2; Metformin; Transcription (linguistics); RNA; Gene isoform; Transcriptional regulation; Biology; Pharmacology; Gene expression; Endocrinology; Chemistry; Internal medicine; Gene; Biochemistry; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177582,0.0001902103,0.0002319773,0.0001468415,0.0001411509,0.0001847967,0.0001170484,0.0001795607,0.000921629],"category_scores_gemma":[0.0001032541,0.0001180142,0.000289095,0.0002100066,0.000152981,0.000115746,0.0001056035,0.00036435,0.0002934601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006019,"about_ca_system_score_gemma":0.0001627117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001672312,"about_ca_topic_score_gemma":0.002619628,"domain_scores_codex":[0.9998621,0.00001867912,0.00001740099,0.00004227061,0.00003521782,0.00002444772],"domain_scores_gemma":[0.9999413,0.00001885961,0.00001031167,0.00001040441,0.0000113561,0.000007688117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001815981,0.00002402657,0.0002258893,0.00001817558,0.000003772019,0.00002874924,0.00002394187,0.00005007133,0.9988558,0.0000340086,0.00002121132,0.0005327156],"study_design_scores_gemma":[0.00001718707,0.0002989361,0.00680177,0.000003235626,0.0000148076,0.0000986114,0.00005037033,0.001117887,0.9902447,0.00002823314,0.001319253,0.000004946479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933518,0.001541628,0.002259342,0.00007786065,0.00002856796,0.00002898271,0.001772174,0.00003006721,0.0009095444],"genre_scores_gemma":[0.9843851,0.001343512,0.006085512,0.00008137662,0.00001817559,0.0001162221,0.003911758,0.00002410417,0.004034294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672312,"threshold_uncertainty_score":0.003325164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009420148517637115,"score_gpt":0.239378234390436,"score_spread":0.2299580858727989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}