{"id":"W3194993324","doi":"10.1021/acsmedchemlett.1c00366","title":"A Potent Fluorescent Reversible-Covalent Inhibitor of Cardiac Muscle Contraction","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"British Heart Foundation; Heart and Stroke Foundation of Canada","keywords":"Covalent bond; Contraction (grammar); Fluorescence; Cardiac muscle; Chemistry; Muscle contraction; Biophysics; Pharmacology; Biochemistry; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228258,0.0001797793,0.000535379,0.00002944868,0.0000626078,0.000006117106,0.00005411499,0.00008867218,0.0000594711],"category_scores_gemma":[0.0001883369,0.0001664668,0.0002695428,0.0001884427,0.0001620548,0.00004195987,0.00006507233,0.0002850098,0.000006903566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001749742,"about_ca_system_score_gemma":0.0001216821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003453038,"about_ca_topic_score_gemma":4.26371e-7,"domain_scores_codex":[0.9984826,0.00003171198,0.0003311028,0.0003185496,0.0005702448,0.0002657427],"domain_scores_gemma":[0.9990757,0.00007085167,0.0001195313,0.0003543808,0.0002249033,0.0001547032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403751,0.0001061656,0.002621279,0.0006251906,0.0002656041,0.0004339084,0.0003264259,0.00000234829,0.973843,0.00000225796,0.01756816,0.004065314],"study_design_scores_gemma":[0.001345634,0.00003573502,0.0203628,0.0005725724,0.0006244704,0.0002721763,0.001862512,0.000002194743,0.9504724,0.000002592609,0.02429821,0.00014867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838082,0.003553296,0.00004901124,0.01015555,0.0006272658,0.0001643926,0.00002092661,0.00003841011,0.001583021],"genre_scores_gemma":[0.99613,0.0007902182,0.0001809901,0.001479165,0.001079977,0.0000159487,0.00006722937,0.00001730873,0.0002391313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02337053,"threshold_uncertainty_score":0.6788321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116362253852705,"score_gpt":0.2366635002778134,"score_spread":0.2254998777392863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}