{"id":"W3194993324","doi":"10.1021/acsmedchemlett.1c00366","title":"A Potent Fluorescent Reversible-Covalent Inhibitor of Cardiac Muscle Contraction","year":2021,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"British Heart Foundation; Heart and Stroke Foundation of Canada","keywords":"Covalent bond; Contraction (grammar); Fluorescence; Cardiac muscle; Chemistry; Muscle contraction; Biophysics; Pharmacology; Biochemistry; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002125373,0.0004445011,0.0001655921,0.000153947,0.0002030292,0.0001663803,0.000506417,0.0005002918,0.002588622],"category_scores_gemma":[0.0001079276,0.0001589152,0.000170577,0.0001055395,0.0001876558,0.0001661761,0.000188058,0.0005843301,0.0005375835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097692,"about_ca_system_score_gemma":0.0002450461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006905925,"about_ca_topic_score_gemma":0.001138089,"domain_scores_codex":[0.9998541,0.00001739934,0.000004820798,0.00004263785,0.00003401864,0.00004715298],"domain_scores_gemma":[0.9999522,0.00001229295,0.00001068864,0.000005623842,0.000004957243,0.00001412545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008002881,0.00005451389,0.00005310563,0.00007653054,0.000007228239,0.00005947032,0.00001326924,0.0001355112,0.9940827,0.0005445523,0.0003989381,0.004494114],"study_design_scores_gemma":[0.00003513124,0.0004931716,0.0007486008,0.000007191741,0.00001043079,0.0002584012,0.000006589783,0.0007899335,0.9893556,0.00003734556,0.008249517,0.000008003609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9185914,0.01025013,0.03692189,0.0004804675,0.0001857105,0.0003063963,0.0008415005,0.0006296318,0.03179283],"genre_scores_gemma":[0.9701509,0.002621453,0.01217064,0.0003251097,0.00003131827,0.0001517525,0.0008000066,0.00002610097,0.01372264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002588622,"threshold_uncertainty_score":0.00865984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116362253852705,"score_gpt":0.2366635002778134,"score_spread":0.2254998777392863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}