{"id":"W3195000164","doi":"10.1126/sciadv.abj0364","title":"Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Saskatchewan Cancer Agency; Vancouver General Hospital; Pancreas Centre (Canada); University of Saskatchewan","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Intracellular; Cell biology; Chemistry; Hypoxia (environmental); Cancer research; Homeostasis; Biochemistry; Biology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591832,0.0004878511,0.0003556712,0.0002991146,0.0001975906,0.0003004341,0.0002265894,0.0003708302,0.001562701],"category_scores_gemma":[0.0001146292,0.0001202591,0.000257708,0.0001617141,0.0002622391,0.0001137207,0.0002497985,0.0004531283,0.0002875285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003982996,"about_ca_system_score_gemma":0.0003285489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009869087,"about_ca_topic_score_gemma":0.002032316,"domain_scores_codex":[0.9998747,0.00001103275,0.00000894541,0.00003941893,0.00004361464,0.00002227208],"domain_scores_gemma":[0.9999063,0.00002068909,0.00003178066,0.000007799566,0.00000868121,0.00002463172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005162091,0.00001279703,0.0002917356,0.00003003888,0.000007308216,0.0001266697,0.000008158263,0.0001806418,0.9976921,0.0001669284,0.00005560289,0.001376448],"study_design_scores_gemma":[0.00002784171,0.0002756492,0.006304188,0.0000101033,0.00005065405,0.0007970008,0.00004529173,0.003905017,0.9821859,0.0001661158,0.006220447,0.00001173235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688022,0.001561778,0.02168152,0.0002930678,0.00006415138,0.0001092824,0.002864004,0.000777172,0.003846949],"genre_scores_gemma":[0.986468,0.0008000256,0.006380973,0.0001063567,0.000008099197,0.00006049395,0.001965684,0.00007608945,0.004134354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562701,"threshold_uncertainty_score":0.005227804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109683956000572,"score_gpt":0.2729898454721041,"score_spread":0.2618930059120984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}