{"id":"W3195015166","doi":"10.1186/s13058-021-01450-7","title":"Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment","year":2021,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"FP7 Ideas: European Research Council; Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council NSW; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; University of California, San Francisco; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Norges Forskningsråd; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Fondation de France; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; National Institute of Environmental Health Sciences; U.S. Army; University of Westminster; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; University of Southern California; Stavros Niarchos Foundation; Deutsche Krebshilfe; Ministère de l'Économie, de la Science et de l'Innovation - Québec; University of California; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; U.S. Department of Defense; Itä-Suomen Yliopisto; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Brigham and Women's Hospital; Cancer Council Victoria; California Department of Public Health; Breast Cancer Research Foundation; Cancer Council Tasmania; World Health Organization","keywords":"Breast cancer; Hazard ratio; Medicine; Oncology; Internal medicine; Surgical oncology; Confidence interval; Germline; Cancer; Proportional hazards model; Allele; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000539076,0.0001631715,0.000371859,0.0001101354,0.00005060237,0.00001367553,0.0001391715,0.0001972813,0.0001874073],"category_scores_gemma":[0.00007996819,0.0001363778,0.00003835038,0.0006740959,0.0001265288,0.000004786424,0.0001346097,0.0001475247,0.000002748363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000594431,"about_ca_system_score_gemma":0.001010004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132949,"about_ca_topic_score_gemma":0.0009769963,"domain_scores_codex":[0.9977016,0.0005714015,0.000482697,0.0005771678,0.0002863516,0.0003807374],"domain_scores_gemma":[0.9983606,0.0001119282,0.0001860096,0.000333032,0.0009119263,0.00009653831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001311804,0.0004091254,0.4235683,0.00006904524,0.0002180865,0.00002674155,0.0002267424,0.0003870257,0.5623849,0.0000439569,0.0005018374,0.01085248],"study_design_scores_gemma":[0.00419637,0.001979341,0.9386593,0.0003849041,0.00007716574,0.0004987124,0.0006817235,0.00008354392,0.05145393,0.00009373769,0.001467753,0.0004235706],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900213,0.007031682,0.00004401471,0.0008015292,0.0001614173,0.0003747558,0.001499461,0.000005189461,0.00006058795],"genre_scores_gemma":[0.9948134,0.004061858,0.0004366338,0.00002422223,0.00006403783,0.0002103762,0.0001351383,0.00002627653,0.0002280383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5150909,"threshold_uncertainty_score":0.5561324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299950959095033,"score_gpt":0.3476092440435634,"score_spread":0.3176141481340601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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