{"id":"W3195015166","doi":"10.1186/s13058-021-01450-7","title":"Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment","year":2021,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"FP7 Ideas: European Research Council; Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council NSW; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; University of California, San Francisco; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Norges Forskningsråd; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Fondation de France; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; National Institute of Environmental Health Sciences; U.S. Army; University of Westminster; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; University of Southern California; Stavros Niarchos Foundation; Deutsche Krebshilfe; Ministère de l'Économie, de la Science et de l'Innovation - Québec; University of California; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; U.S. Department of Defense; Itä-Suomen Yliopisto; Genome Canada; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Brigham and Women's Hospital; Cancer Council Victoria; California Department of Public Health; Breast Cancer Research Foundation; Cancer Council Tasmania; World Health Organization","keywords":"Breast cancer; Hazard ratio; Medicine; Oncology; Internal medicine; Surgical oncology; Confidence interval; Germline; Cancer; Proportional hazards model; Allele; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001040154,0.0002695511,0.0004628254,0.0004822049,0.0002986587,0.0004455785,0.0002840355,0.0005045379,0.001215145],"category_scores_gemma":[0.002792435,0.0001325939,0.0008666096,0.0005464267,0.0003501592,0.0001828236,0.0003453928,0.000435956,0.0001071734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778499,"about_ca_system_score_gemma":0.0002317487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372293,"about_ca_topic_score_gemma":0.001916949,"domain_scores_codex":[0.9991543,0.0001879853,0.00007557678,0.0003440936,0.00009975679,0.0001381959],"domain_scores_gemma":[0.9975555,0.001064154,0.0008478314,0.0002665003,0.0000874307,0.0001785067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000759504,0.00002075292,0.9937068,0.0000103406,0.0004805741,0.0001239784,0.000045695,0.000315575,0.002513755,0.00003663481,0.00005182893,0.001934501],"study_design_scores_gemma":[0.0000437239,0.0001871736,0.9967354,0.000004246461,0.0003121615,0.0006210971,0.00005772045,0.001144326,0.0005400466,0.0002054069,0.0001421646,0.000006532882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993702,0.0001451495,0.0002236804,0.00001791068,0.000002495126,0.000002436908,0.0001385693,0.00000328635,0.00009625449],"genre_scores_gemma":[0.9997534,0.00001541263,0.00005979149,0.000008875193,0.0000026434,0.000002076785,0.0001339811,0.000001642585,0.00002222311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372293,"threshold_uncertainty_score":0.005500972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299950959095033,"score_gpt":0.3476092440435634,"score_spread":0.3176141481340601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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